Impaired FEF25-75 may predict high exhaled nitric oxide values in children with allergic rhinitis and/or asthma

Giorgio Ciprandi, M. A. Tosca, I. Cirillo, E. Lionetti, S. Leonardi, M. Miraglia Del Giudice, M. La Rosa, A. Salpietro, M. Capasso, G. L. Marseglia

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Allergic rhinitis and asthma are closely associated. Inflammation is a common pathological characteristic shared by both disorders. The measure of the fractional concentration of exhaled nitric oxide (FeNO) may be considered a surrogate marker for airway inflammation. Forced expiratory flow between 25% and 75% of vital capacity (FEF25-75) has been previously demonstrated to be able to predict BHR and bronchial reversibility. The aim of this study was to evaluate whether impaired FEF25-75 values may be related to FeNO values in a pediatric cohort of allergic subjects. 850 children with allergic rhinitis, allergic asthma, or both, were evaluated. Bronchial function (FEV 1, FVC, and FEF25-75), FeNO, and sensitizations were assessed. Bronchial function and FeNO were significantly different in the 3 groups (p1 was found in patients with rhinitis, asthma and asthma with rhinitis (r=-0.72, r=-0.70 and r=-0.70, respectively). Impaired FEF 25-75 values (such as 25-75 is strongly and inversely related with FeNO and FEF25-75 may predict high FeNO levels in children with allergic rhinitis, asthma or both.

Original languageEnglish
JournalJournal of Biological Regulators and Homeostatic Agents
Volume26
Issue number1 SUPPL
Publication statusPublished - 2012

Fingerprint

Vital Capacity
Nitric Oxide
Asthma
Rhinitis
Inflammation
Allergic Rhinitis
Biomarkers
Pediatrics

Keywords

  • Allergic rhinitis
  • Asthma
  • Children
  • FEF
  • Nitric oride

ASJC Scopus subject areas

  • Oncology
  • Endocrinology, Diabetes and Metabolism
  • Physiology (medical)
  • Immunology and Allergy
  • Immunology
  • Endocrinology
  • Physiology
  • Cancer Research

Cite this

Impaired FEF25-75 may predict high exhaled nitric oxide values in children with allergic rhinitis and/or asthma. / Ciprandi, Giorgio; Tosca, M. A.; Cirillo, I.; Lionetti, E.; Leonardi, S.; Miraglia Del Giudice, M.; La Rosa, M.; Salpietro, A.; Capasso, M.; Marseglia, G. L.

In: Journal of Biological Regulators and Homeostatic Agents, Vol. 26, No. 1 SUPPL, 2012.

Research output: Contribution to journalArticle

Ciprandi, G, Tosca, MA, Cirillo, I, Lionetti, E, Leonardi, S, Miraglia Del Giudice, M, La Rosa, M, Salpietro, A, Capasso, M & Marseglia, GL 2012, 'Impaired FEF25-75 may predict high exhaled nitric oxide values in children with allergic rhinitis and/or asthma', Journal of Biological Regulators and Homeostatic Agents, vol. 26, no. 1 SUPPL.
Ciprandi, Giorgio ; Tosca, M. A. ; Cirillo, I. ; Lionetti, E. ; Leonardi, S. ; Miraglia Del Giudice, M. ; La Rosa, M. ; Salpietro, A. ; Capasso, M. ; Marseglia, G. L. / Impaired FEF25-75 may predict high exhaled nitric oxide values in children with allergic rhinitis and/or asthma. In: Journal of Biological Regulators and Homeostatic Agents. 2012 ; Vol. 26, No. 1 SUPPL.
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