Impaired FEF25-75 may predict high exhaled nitric oxide values in children with allergic rhinitis and/or asthma

Giorgio Ciprandi, M. A. Tosca, I. Cirillo, E. Lionetti, S. Leonardi, M. Miraglia Del Giudice, M. La Rosa, A. Salpietro, M. Capasso, G. L. Marseglia

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Allergic rhinitis and asthma are closely associated. Inflammation is a common pathological characteristic shared by both disorders. The measure of the fractional concentration of exhaled nitric oxide (FeNO) may be considered a surrogate marker for airway inflammation. Forced expiratory flow between 25% and 75% of vital capacity (FEF25-75) has been previously demonstrated to be able to predict BHR and bronchial reversibility. The aim of this study was to evaluate whether impaired FEF25-75 values may be related to FeNO values in a pediatric cohort of allergic subjects. 850 children with allergic rhinitis, allergic asthma, or both, were evaluated. Bronchial function (FEV 1, FVC, and FEF25-75), FeNO, and sensitizations were assessed. Bronchial function and FeNO were significantly different in the 3 groups (p1 was found in patients with rhinitis, asthma and asthma with rhinitis (r=-0.72, r=-0.70 and r=-0.70, respectively). Impaired FEF 25-75 values (such as 25-75 is strongly and inversely related with FeNO and FEF25-75 may predict high FeNO levels in children with allergic rhinitis, asthma or both.

Original languageEnglish
JournalJournal of Biological Regulators and Homeostatic Agents
Issue number1 SUPPL
Publication statusPublished - 2012


  • Allergic rhinitis
  • Asthma
  • Children
  • FEF
  • Nitric oride

ASJC Scopus subject areas

  • Oncology
  • Endocrinology, Diabetes and Metabolism
  • Physiology (medical)
  • Immunology and Allergy
  • Immunology
  • Endocrinology
  • Physiology
  • Cancer Research


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