Impaired glucose tolerance, endocrine and metabolism abnormalities in families of patients with type 2 diabetes mellitus

A. E. Pontiroli, P. M. Piatti, M. G. Perfetti, G. Pozza

Research output: Contribution to journalArticle

Abstract

Early metabolic defects were studied and identified in 33 nondiabetic first degree relatives (FDR) of subjects with noninsulin dependent diabetes mellitus (NIDDM) (Group I), and in 31 control subjects (Group II) matched for age and body mass index (BMI) with no family history of diabetes (14 with impaired, and 17 with normal glucose tolerance (IGT, and NGT, resp.). The conclusion was that IGT is frequent among FDR of subjects with NIDDM; a mild hyperinsulinemia is present before the appearance of glucose intolerance and an impaired insulin action on glucose metabolism and lipolysis is present in FDR with IGT.

Original languageEnglish
Pages (from-to)227-230
Number of pages4
JournalArchives of Gerontology and Geriatrics
Volume12
Issue numberSUPPL. 2
Publication statusPublished - 1991

Keywords

  • impaired glucose tolerance
  • insulin action
  • insulin secretion
  • NIDDM

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)

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