Impaired immune response to candida albicans in cells from fanconi anemia patients

Alessia Parodi, Francesca Kalli, Johanna Svahn, Giorgia Stroppiana, Daniela De Rocco, Paola Terranova, Carlo Dufour, Daniela Fenoglio, Enrico Cappelli

Research output: Contribution to journalArticle

Abstract

Fanconi anemia (FA) is a genetic disorder characterized by bone marrow failure and cancer predisposition. Several studies show alterations of the immunological status of FA patients including defects in peripheral blood lymphocyte subsets, serum immunoglobulin levels, and inflammatory cytokines. However scanty information is available on the response of FA cells to specific infectious antigens. In this work we examined the response of FA cells to different immunological stimuli and found a defective response of IL-1β, TNF-α and IL-17 to Candida albicans stimulation thus pointing to a potentially impaired response to fungal infections of FA patients.

Original languageEnglish
Pages (from-to)203-207
Number of pages5
JournalCytokine
Volume73
Issue number1
DOIs
Publication statusPublished - May 1 2015

Keywords

  • Candida albicans
  • Fanconi anemia
  • IL-17
  • IL-1β
  • TNF-α

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Hematology
  • Biochemistry
  • Molecular Biology
  • Medicine(all)

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  • Cite this

    Parodi, A., Kalli, F., Svahn, J., Stroppiana, G., De Rocco, D., Terranova, P., Dufour, C., Fenoglio, D., & Cappelli, E. (2015). Impaired immune response to candida albicans in cells from fanconi anemia patients. Cytokine, 73(1), 203-207. https://doi.org/10.1016/j.cyto.2015.02.016