Impaired in vitro growth of PHA induced T lymphocyte colonies in hemodialyzed renal failure patients

Riccardo Ghio, Enrico Haupt, Vito Pistoia, Angela Perata, Paola Minale, Massimo Ratti, Piero Boccaccio

Research output: Contribution to journalArticlepeer-review

Abstract

Using an in vitro method that allows the study of the colony forming capacity of phytohemagglutinin stimulated peripheral blood T lymphocytes, we have detected an impaired T cell colony formation in hemodialyzed renal failure patients. By contrast a near normal pattern of responses was observed in patients treated with a conservative therapy. The poor in vitro T cell responsiveness of hemodialyzed patients was not corrected by supplementing the cultures with an adherent cell contitioned medium prepared from normal donors. We conclude that an intrinsic defect of the T cell colony forming capacity exists in hemodialyzed patients.

Original languageEnglish
Pages (from-to)135-140
Number of pages6
JournalBlut
Volume50
Issue number3
DOIs
Publication statusPublished - Mar 1985

Keywords

  • Chronic Renal Failure
  • T lymphocyte Colony Formation

ASJC Scopus subject areas

  • Hematology

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