Impaired insulin-like growth factor I vasorelaxant effects in hypertension

Carmine Vecchione, Salvatore Colella, Luigi Fratta, Maria Teresa Gentile, Giulio Selvetella, Giacomo Frati, Bruno Trimarco, Giuseppe Lembo

Research output: Contribution to journalArticlepeer-review


Insulin-like growth factor I (IGF-I) can be considered a factor potentially involved in arterial hypertension not only for its growth-promoting features but also for its effects on vascular tone. Nevertheless, the actions of the hormone on vascular reactivity are still unexplored in hypertension. Therefore, the vasodilation induced by increasing doses of IGF-I and the modulation of norepinephrine vasoconstriction induced by low levels of the hormone were tested on aortic rings of spontaneously hypertensive and normotensive rats. The results indicate that the vasodilation evoked by IGF-I is impaired in hypertensive rats (Δ% of maximal vasorelaxation, 30±1 versus 41±1; P2-adrenergic-evoked NO vasorelaxation. The defect in IGF-I vascular action is also present in young spontaneously hypertensive rats (age 5 weeks). In conclusion, our data demonstrate that IGF-I vasorelaxant properties are impaired in spontaneously hypertensive rats, suggesting that such defect may play a causative or permissive role in the development of hypertensive conditions.

Original languageEnglish
Pages (from-to)1480-1485
Number of pages6
Issue number6
Publication statusPublished - 2001


  • Aorta
  • Nitric oxide
  • Norepinephrine
  • Receptors, adrenergic, alpha
  • Vascular reactivity

ASJC Scopus subject areas

  • Internal Medicine


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