Impaired insulin secretion in human diabetes mellitus. I. The effect of alpha-adrenergic inhibition

D. Giugliano; T. Cerciello; G. Giannetti; A. Ceriello; R. Giunta; N. Frascolla

doi:10.1016/S0031-6989(82)80031-3

Impaired insulin secretion in human diabetes mellitus. I. The effect of alpha-adrenergic inhibition

D. Giugliano, T. Cerciello, G. Giannetti, A. Ceriello, R. Giunta, N. Frascolla

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Abstract

The effect of nicergoline, an alpha-adrenergic blocking drug, upon insulin response to glucose has been investigated in 8 subjects with Type II (adult-onset) diabetes mellitus with fasting hyperglycemia. All subjects had no acute insulin response to intravenous glucose (20 g) pulse (AIR=Acute Insulin Response=1±5%, mean±SEM, mean change 3-10 min, % basal). Nicergoline infusion (0.1 mg/min) resulted in both a partial restoration of AIR (43±12 %, p

Original language	English
Pages (from-to)	217-225
Number of pages	9
Journal	Pharmacological Research Communications
Volume	14
Issue number	3
DOIs	https://doi.org/10.1016/S0031-6989(82)80031-3
Publication status	Published - 1982

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ASJC Scopus subject areas

Pharmacology

Cite this

Giugliano, D., Cerciello, T., Giannetti, G., Ceriello, A., Giunta, R., & Frascolla, N. (1982). Impaired insulin secretion in human diabetes mellitus. I. The effect of alpha-adrenergic inhibition. Pharmacological Research Communications, 14(3), 217-225. https://doi.org/10.1016/S0031-6989(82)80031-3

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10.1016/S0031-6989(82)80031-3