TY - JOUR
T1 - Impaired insulin secretion in human diabetes mellitus. I. The effect of alpha-adrenergic inhibition
AU - Giugliano, D.
AU - Cerciello, T.
AU - Giannetti, G.
AU - Ceriello, A.
AU - Giunta, R.
AU - Frascolla, N.
PY - 1982
Y1 - 1982
N2 - The effect of nicergoline, an alpha-adrenergic blocking drug, upon insulin response to glucose has been investigated in 8 subjects with Type II (adult-onset) diabetes mellitus with fasting hyperglycemia. All subjects had no acute insulin response to intravenous glucose (20 g) pulse (AIR=Acute Insulin Response=1±5%, mean±SEM, mean change 3-10 min, % basal). Nicergoline infusion (0.1 mg/min) resulted in both a partial restoration of AIR (43±12 %, p
AB - The effect of nicergoline, an alpha-adrenergic blocking drug, upon insulin response to glucose has been investigated in 8 subjects with Type II (adult-onset) diabetes mellitus with fasting hyperglycemia. All subjects had no acute insulin response to intravenous glucose (20 g) pulse (AIR=Acute Insulin Response=1±5%, mean±SEM, mean change 3-10 min, % basal). Nicergoline infusion (0.1 mg/min) resulted in both a partial restoration of AIR (43±12 %, p
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U2 - 10.1016/S0031-6989(82)80031-3
DO - 10.1016/S0031-6989(82)80031-3
M3 - Article
C2 - 6124977
AN - SCOPUS:0019982295
VL - 14
SP - 217
EP - 225
JO - Pharmacological Research
JF - Pharmacological Research
SN - 1043-6618
IS - 3
ER -