Impaired left ventricular energy metabolism in patients with hypertrophic cardiomyopathy is related to the extension of fibrosis at delayed gadolinium-enhanced magnetic resonance imaging

A. Esposito, F. De Cobelli, G. Perseghin, M. Pieroni, E. Belloni, R. Mellone, T. Canu, F. Gentinetta, P. Scifo, C. Chimenti, A. Frustaci, L. Luzi, A. Maseri, A. Del Maschio

Research output: Contribution to journalArticle

Abstract

Objective: Areas of intramyocardial late enhancement (LE) at delayed enhanced magnetic resonance imaging (DE-MRI) and reduction of myocardial phosphocreatine (PCr)/ATP-ratio at phosphorus magnetic resonance spectroscopy (p31pP-MRS) are both reported in hypertrophic cardiomyopathy (HCM) and indicate areas of increased interstitial myocardial space with fibrosis and impairment of myocardial energy metabolism, respectively. We sought to ascertain whether in HCM patients the abnormal features of left ventricular (LV) interstitial space revealed by DE-MRI correlated with impaired LV energy metabolism shown at p31pP-MRS. Methods: 19 patients with HCM proved by histological analysis of multiple endomyocardial biopsies and with normal coronary arteries, underwent cardiac MRI including DE-MRI and p31pP-MRS. DE-MRI for detection and quantification of late enhancement (LE) and p31pP-MRS to assess the myocardial PCr/ATP-ratio were performed by means of a 1.5-T magnet. 19 healthy subjects, matched for gender and age were studied by p31pP-MRS as control group. Results: LE areas in the LV wall were found in 17 out of 19 patients with an extension ranging from 0.8% to 19.5% of the LV-mass (mean value 7.6% (SD 5.6%). The PCr/ATP-ratio was lower in HCM patients than in control subjects (2.18 (0.41) vs 2.41 (0.30); p

Original languageEnglish
Pages (from-to)228-233
Number of pages6
JournalHeart
Volume95
Issue number3
DOIs
Publication statusPublished - Feb 2009

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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