Impaired midwall mechanics and biventricular hypertrophy in essential hypertension

Cesare Cuspidi, Francesca Negri, Valentina Giudici, Carla Sala, Giuseppe Mancia

Research output: Contribution to journalArticlepeer-review


Objective. Impaired left ventricular (LV) mechanics in human hypertension are strongly related to LV hypertrophy (LVH). In the present study, we investigated the relationship between LV mid-wall fractional shortening (MWS) and biventricular hypertrophy in uncomplicated essential hypertensives. Methods. A total of 328 hypertensive patients categorized in tertiles of MWS were considered for the analysis. All patients underwent routine and standardized echocardiographic examinations. Biventricular hypertrophy was defined by anterior right ventricular (RV) wall thickness ≥3.1 mm/m2 in men and ≥3.0 mm/m2 in women, combined with LV mass index (LVMI) ≥49 g/m2.7 in men and 45 g/m2.7 in women. Results. Biventricular hypertrophy was found in 21% of the study population. In the lowest MWS tertile, the likelihood of biventricular hypertrophy was 1.4- and 1.9-fold greater (p

Original languageEnglish
Pages (from-to)234-239
Number of pages6
JournalBlood Pressure
Issue number4
Publication statusPublished - Aug 2010


  • Biventricular hypertrophy
  • Hypertension
  • Left ventricular mechanics

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine


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