Impaired movement control in Alzheimer's disease

M. Felice Ghilardi, Margherita Alberoni, Sabrina Marelli, Marina Rossi, Massimo Franceschi, Claude Ghez, Ferruccio Fazio

Research output: Contribution to journalArticle

Abstract

Movement accuracy in normal subjects depends on feedforward commands based on representation in memory of spatial and biomechanical features. Here we ask whether memory deficits in Alzheimer's disease (AD) interfere with movement planning and execution. Nine AD patients and nine age-matched controls moved a cursor to targets without seeing their limb. Starting and target positions were always visible on a screen, while, during movement, cursor position was either visible or blanked. Patients' paths showed discontinuous segments and prolonged movement time; movement inaccuracy, which increased without visual feedback, correlated significantly with scores of disease severity, working memory and attention.

Original languageEnglish
Pages (from-to)45-48
Number of pages4
JournalNeuroscience Letters
Volume260
Issue number1
DOIs
Publication statusPublished - Jan 22 1999

Keywords

  • Alzheimer's disease
  • Bradykinesia
  • Humans
  • Kinematics
  • Reaching movements

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Impaired movement control in Alzheimer's disease'. Together they form a unique fingerprint.

  • Cite this

    Ghilardi, M. F., Alberoni, M., Marelli, S., Rossi, M., Franceschi, M., Ghez, C., & Fazio, F. (1999). Impaired movement control in Alzheimer's disease. Neuroscience Letters, 260(1), 45-48. https://doi.org/10.1016/S0304-3940(98)00957-4