Impaired movement control in Alzheimer's disease

M. Felice Ghilardi, Margherita Alberoni, Sabrina Marelli, Marina Rossi, Massimo Franceschi, Claude Ghez, Ferruccio Fazio

Research output: Contribution to journalArticle


Movement accuracy in normal subjects depends on feedforward commands based on representation in memory of spatial and biomechanical features. Here we ask whether memory deficits in Alzheimer's disease (AD) interfere with movement planning and execution. Nine AD patients and nine age-matched controls moved a cursor to targets without seeing their limb. Starting and target positions were always visible on a screen, while, during movement, cursor position was either visible or blanked. Patients' paths showed discontinuous segments and prolonged movement time; movement inaccuracy, which increased without visual feedback, correlated significantly with scores of disease severity, working memory and attention.

Original languageEnglish
Pages (from-to)45-48
Number of pages4
JournalNeuroscience Letters
Issue number1
Publication statusPublished - Jan 22 1999


  • Alzheimer's disease
  • Bradykinesia
  • Humans
  • Kinematics
  • Reaching movements

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Ghilardi, M. F., Alberoni, M., Marelli, S., Rossi, M., Franceschi, M., Ghez, C., & Fazio, F. (1999). Impaired movement control in Alzheimer's disease. Neuroscience Letters, 260(1), 45-48.