Impaired prolactin secretion in obese patients

Francesco Cavagnini, C. Maraschini, M. Pinto, A. Dubini, E. E. Polli

Research output: Contribution to journalArticlepeer-review


To investigate a possible hypothalamic alteration in obesity, we have studied the pattern of PRL secretion in response to insulin hypoglycemia, arginine infusion and TRH injection in 12 grossly obese patients and in 12 normal-weight controls. In the obese patients, PRL secretion was significantly lower than in normal subjects in response to insulin hypoglycemia and arginine infusion, while it was not significantly different from that in controls in response to TRH. The mean ± SE values of the areas subtended by the PRL curves in the 3 above tests were 54.7 ± 155.81 vs 3677.3 ± 520.30 ng/2h,p

Original languageEnglish
Pages (from-to)149-153
Number of pages5
JournalJournal of Endocrinological Investigation
Issue number2
Publication statusPublished - 1981


  • fasting
  • hypothalamus
  • obesity
  • pituitary
  • Prolactin

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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