Impaired response to hepatitis B vaccine in HIV infected children

G. Zuin, N. Principi, R. Tornaghi, S. Paccagnini, M. Re, E. Massironi, M. C. Ragni

Research output: Contribution to journalArticlepeer-review


Eighteen human immunodeficiency virus (HIV) vertically infected children (HIV group) and 33 seroreverted children (SR group), who had completed hepatitis B vaccination (Engerix B, 20 μg dose) were studied. Four out of 18 (22%) HIV children failed to develop protective antibody levels (anti-HBs titres <10 mIU ml-1) compared with 1 out of 33 (3%) SR children (p <0.05). Magnitude of response among HIV children was significantly lower than among SR children. In HIV children the probability that anti-HBs titres persist above the protective levels was significantly lower than in the SR group at any time during the 24 month follow-up. These results show that HIV children have a suboptimal response to hepatitis B immunization and the protection is less durable. Further studies are needed to determine the optimal protocol for hepatitis B immunization in HIV children.

Original languageEnglish
Pages (from-to)857-860
Number of pages4
Issue number12
Publication statusPublished - 1992


  • children
  • hepatitis B vaccine
  • Human immunodeficiency virus (HIV)
  • impaired response

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)


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