Impaired working memory and normal sustained attention in borderline personality disorder

Matteo Lazzaretti, Niccolò Morandotti, Michela Sala, Miriam Isola, Sophia Frangou, Giulia De Vidovich, Elisa Marraffini, Francesca Gambini, Francesco Barale, Federico Zappoli, Edgardo Caverzasi, Paolo Brambilla

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Although reports in the literature describe deficits in working memory in borderline personality disorder (BPD), the evidence is limited and inconsistent. The aim of this study was to evaluate further this cognitive dimension and its clinical correlates in BPD. Method: We compared the performance of 15 BPD patients to 1:1 matched healthy controls on verbal working memory as determined by the sequential letter N-back test and sustained attention as measured using the continuous performance test (CPT). Results: BPD patients performed significantly worse on the N-back test compared to healthy controls (p <0.05), but not on the CPT. The N-back deficit was more pronounced and significant in the 3-back condition and inversely correlated with impulsivity. Conclusions: These results suggest the presence of working memory deficits in BPD that may be linked to greater impulsivity and sustained by impairment in the dorsolateral prefrontal cortex.

Original languageEnglish
Pages (from-to)349-355
Number of pages7
JournalActa Neuropsychiatrica
Volume24
Issue number6
DOIs
Publication statusPublished - Dec 2012

Keywords

  • borderline personality disorder
  • continuous performance test
  • impulsivity
  • N-back test
  • sustained attention
  • verbal working memory

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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