Impairment measures versus inflammatory RODS in GBS and CIDP: A responsiveness comparison

Els K. Vanhoutte, Thomas H P Draak, Kenneth C. Gorson, Sonja I. Van Nes, Janneke G J Hoeijmakers, W. Ludo Van Der Pol, Nicolette C. Notermans, Richard A. Lewis, Eduardo Nobile-Orazio, Jean Marc Léger, Peter Y K Van Den Bergh, Giuseppe Lauria, Vera Bril, Hans Katzberg, Michael P T Lunn, Jean Pouget, Anneke J. Van Der Kooi, Angelika F. Hahn, Pieter A. Van Doorn, David R. CornblathLeonard H. Van Den Berg, Catharina G. Faber, Ingemar S J Merkies

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

This study aimed to 'define responder' through the concept of minimum clinically important differences using the individually obtained standard errors (MCID-SE) and a heuristic 'external criterion' responsiveness method in patients with Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). One hundred and fourteen newly diagnosed or relapsing patients (GBS: 55, CIDP: 59) were serially examined (1-year follow-up). The inflammatory Rasch-built overall disability scale (I-RODS), Rasch-transformed MRC sum score (RT-MRC), and Rasch-transformed modified-INCAT-sensory scale (RT-mISS) were assessed. Being-a-responder was defined as having a MCID-SE cut-off ≥1.96. Also, the correlations between patients' scores on each scale and the EuroQoL health-status 'thermometer' (external criterion) were determined (higher correlation indicated better responsiveness). In both diseases, the SEs showed a characteristic 'U'-shaped dynamic pattern across each scales' continuum. The number of patients showing a meaningful change were higher for the I-RODS > RT-MRC > RT-mISS and were in GBS higher than CIDP patients. The MCID-SE concept using Rasch-transformed data demonstrated an individual pattern of 'being-a-responder' in patients with immune-mediated neuropathies, and the findings were validated by the external criterion responsiveness method. The I-RODS showed greater responsiveness compared with the MRC and INCAT-sensory scales, and its use is therefore recommended in future trials in GBS and CIDP.

Original languageEnglish
Pages (from-to)289-295
Number of pages7
JournalJournal of the Peripheral Nervous System
Volume20
Issue number3
DOIs
Publication statusPublished - Sep 1 2015

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Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Thermometers
Health Status

Keywords

  • immune-mediated neuropathies
  • minimum clinically important difference
  • outcome measure
  • Rasch

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Vanhoutte, E. K., Draak, T. H. P., Gorson, K. C., Van Nes, S. I., Hoeijmakers, J. G. J., Van Der Pol, W. L., ... Merkies, I. S. J. (2015). Impairment measures versus inflammatory RODS in GBS and CIDP: A responsiveness comparison. Journal of the Peripheral Nervous System, 20(3), 289-295. https://doi.org/10.1111/jns.12118

Impairment measures versus inflammatory RODS in GBS and CIDP : A responsiveness comparison. / Vanhoutte, Els K.; Draak, Thomas H P; Gorson, Kenneth C.; Van Nes, Sonja I.; Hoeijmakers, Janneke G J; Van Der Pol, W. Ludo; Notermans, Nicolette C.; Lewis, Richard A.; Nobile-Orazio, Eduardo; Léger, Jean Marc; Van Den Bergh, Peter Y K; Lauria, Giuseppe; Bril, Vera; Katzberg, Hans; Lunn, Michael P T; Pouget, Jean; Van Der Kooi, Anneke J.; Hahn, Angelika F.; Van Doorn, Pieter A.; Cornblath, David R.; Van Den Berg, Leonard H.; Faber, Catharina G.; Merkies, Ingemar S J.

In: Journal of the Peripheral Nervous System, Vol. 20, No. 3, 01.09.2015, p. 289-295.

Research output: Contribution to journalArticle

Vanhoutte, EK, Draak, THP, Gorson, KC, Van Nes, SI, Hoeijmakers, JGJ, Van Der Pol, WL, Notermans, NC, Lewis, RA, Nobile-Orazio, E, Léger, JM, Van Den Bergh, PYK, Lauria, G, Bril, V, Katzberg, H, Lunn, MPT, Pouget, J, Van Der Kooi, AJ, Hahn, AF, Van Doorn, PA, Cornblath, DR, Van Den Berg, LH, Faber, CG & Merkies, ISJ 2015, 'Impairment measures versus inflammatory RODS in GBS and CIDP: A responsiveness comparison', Journal of the Peripheral Nervous System, vol. 20, no. 3, pp. 289-295. https://doi.org/10.1111/jns.12118
Vanhoutte EK, Draak THP, Gorson KC, Van Nes SI, Hoeijmakers JGJ, Van Der Pol WL et al. Impairment measures versus inflammatory RODS in GBS and CIDP: A responsiveness comparison. Journal of the Peripheral Nervous System. 2015 Sep 1;20(3):289-295. https://doi.org/10.1111/jns.12118
Vanhoutte, Els K. ; Draak, Thomas H P ; Gorson, Kenneth C. ; Van Nes, Sonja I. ; Hoeijmakers, Janneke G J ; Van Der Pol, W. Ludo ; Notermans, Nicolette C. ; Lewis, Richard A. ; Nobile-Orazio, Eduardo ; Léger, Jean Marc ; Van Den Bergh, Peter Y K ; Lauria, Giuseppe ; Bril, Vera ; Katzberg, Hans ; Lunn, Michael P T ; Pouget, Jean ; Van Der Kooi, Anneke J. ; Hahn, Angelika F. ; Van Doorn, Pieter A. ; Cornblath, David R. ; Van Den Berg, Leonard H. ; Faber, Catharina G. ; Merkies, Ingemar S J. / Impairment measures versus inflammatory RODS in GBS and CIDP : A responsiveness comparison. In: Journal of the Peripheral Nervous System. 2015 ; Vol. 20, No. 3. pp. 289-295.
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