Impairment of bone status in patients with central diabetes insipidus

Rosario Pivonello, Annamaria Colao, Carolina Di Somma, Giuseppina Facciolli, Michele Klain, Antongiulio Faggiano, Marco Salvatore, Gaetano Lombardi

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The aim of the current study was to evaluate the biochemical parameters of bone metabolism and the bone mineral density (BMD) in patients with central diabetes insipidus, either treated or not treated with endonasal desmopressin. Eighteen patients with central diabetes insipidus and 18 sex- and age-matched healthy subjects entered the study. The patients were divided into 2 groups: patients who did not receive treatment with desmopressin for at least 1 yr (group 1), and patients chronically treated with desmopressin since the diagnosis of diabetes insipidus (group 2). Serum osteocalcin and urinary cross-linked N-telopeptide of type I collagen levels were measured in all patients and controls using RIA and enzyme-linked immunosorbent assay kits, respectively. BMD was measured at the lumbar spine (L1-L4) and at the femoral neck in all subjects, using a Hologic QDR 1000 analyzer (Hologic Inc., Waltham, MA). Serum osteocalcin concentrations were significantly lower, both in patients of group I and group 2, compared with healthy subjects (5.1 ± 0.6 and 4.5 ± 0.3 vs. 7.9 ± 0.2 μg/L, P <0.05), whereas urinary cross-linked N-telopeptide of type I collagen concentrations were similar in the three groups of subjects (72.8 ± 2.2, 71.6 ± 2.7, and 64.6 ± 1.7 nmol bone collagen equivalent/mmol creatinine). BMD was significantly decreased in patients of groups 1 and 2, compared with controls, both at lumbar spine (0.84 ± 0.06 and 0.87 ± 0.04 vs. 1.01 ± 0.02 g/cm2, P <0.05) and femoral neck (0.78 ± 0.06 and 0.80 ± 0.04 vs. 0.93 ± 0.02 g/cm2, P <0.05). A significant inverse correlation was found between disease duration and BMD values, evaluated as T scores, both at lumbar spine (group 1: r = -0.952, P <0.005; group 2: r = -0.921, P <0.001) and at femoral neck (group 1: r = -0.914, P <0.05; group 2: r = -0.683, P <0.05). In conclusion, patients with central diabetes insipidus had a significant bone impairment, compared with healthy subjects. Replacement with endonasal desmopressin at standard doses was not able to prevent or reverse the bone impairment. These findings suggest that, in patients with central diabetes insipidus, bone status analysis is mandatory; and a bone-loss preventing treatment might be beneficial.

Original languageEnglish
Pages (from-to)2275-2280
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Issue number7
Publication statusPublished - 1998


ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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