Impairment of brain neurotransmitter receptors in aged rats

S. Govoni, M. Memo, L. Saiani, P. F. Spano, M. Trabucchi

Research output: Contribution to journalArticle

Abstract

Dopamine and gamma-aminobutyric acid (GABA) receptor functions have been measured in various brain areas of aged rats. [3H] Spiroperidol binding is decreased in various dopaminergic brain areas, particularly in striatum and tuberculum olfactorium. In striatum the number of binding sites for [3H] spiroperidol is similar in both groups of animals, while the affinity is reduced in senescent rats. Moreover, in the pituitary a 50% increase of [3H] spiroperidol binding was detected in the group of senescent animals. On the other hand, [3H]GABA binding is significantly decreased in substantia nigra and hypothalamus of aged rats, while it is unmodified in cerebral cortex, cerebellum, striatum and nucleus accumbens.

Original languageEnglish
Pages (from-to)39-46
Number of pages8
JournalMechanisms of Ageing and Development
Volume12
Issue number1
DOIs
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Ageing
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience

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