Impairment of brain neurotransmitter receptors in aged rats

S. Govoni, M. Memo, L. Saiani, P. F. Spano, M. Trabucchi

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Dopamine and gamma-aminobutyric acid (GABA) receptor functions have been measured in various brain areas of aged rats. [3H] Spiroperidol binding is decreased in various dopaminergic brain areas, particularly in striatum and tuberculum olfactorium. In striatum the number of binding sites for [3H] spiroperidol is similar in both groups of animals, while the affinity is reduced in senescent rats. Moreover, in the pituitary a 50% increase of [3H] spiroperidol binding was detected in the group of senescent animals. On the other hand, [3H]GABA binding is significantly decreased in substantia nigra and hypothalamus of aged rats, while it is unmodified in cerebral cortex, cerebellum, striatum and nucleus accumbens.

Original languageEnglish
Pages (from-to)39-46
Number of pages8
JournalMechanisms of Ageing and Development
Volume12
Issue number1
DOIs
Publication statusPublished - 1980

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Spiperone
Neurotransmitter Receptor
Rats
Brain
Animals
GABA Receptors
Nucleus Accumbens
Substantia Nigra
Cerebral Cortex
Cerebellum
gamma-Aminobutyric Acid
Hypothalamus
Dopamine
Binding Sites

ASJC Scopus subject areas

  • Ageing
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience

Cite this

Impairment of brain neurotransmitter receptors in aged rats. / Govoni, S.; Memo, M.; Saiani, L.; Spano, P. F.; Trabucchi, M.

In: Mechanisms of Ageing and Development, Vol. 12, No. 1, 1980, p. 39-46.

Research output: Contribution to journalArticle

Govoni, S, Memo, M, Saiani, L, Spano, PF & Trabucchi, M 1980, 'Impairment of brain neurotransmitter receptors in aged rats', Mechanisms of Ageing and Development, vol. 12, no. 1, pp. 39-46. https://doi.org/10.1016/0047-6374(80)90027-5
Govoni, S. ; Memo, M. ; Saiani, L. ; Spano, P. F. ; Trabucchi, M. / Impairment of brain neurotransmitter receptors in aged rats. In: Mechanisms of Ageing and Development. 1980 ; Vol. 12, No. 1. pp. 39-46.
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