Contrazione della diuresi in corso di intervento chirurgico. Ruolo delle prostaglandine urinarie.

Translated title of the contribution: Impairment of diuresis in surgical intervention. Role of urinary prostaglandins

A. Mattei, F. Chiumiento, T. Cusano, G. Di Minno, F. Cirillo, G. Vecchione, A. Viglietto, D. Russo, A. Viglietto

Research output: Contribution to journalArticlepeer-review

Abstract

In 8 patients who underwent abdominal surgery for non-neoplastic reasons, we have evaluated some parameters of renal function (PRP, NaU, GFR and diuresis) plasma levels of PRA and ADH and urinary prostaglandins PGE2 and 6-keto-PGF1 alpha. In 4 patients we found that surgery per se was associated with enhancements of PRA, ADH and 6-keto-PGF1 alpha. In other 4 patients, Indomethacin, a specific inhibitor of prostaglandin synthesis was given and this was followed by impairment of natriuresis and RPF. These data confirm the central role of prostaglandins in the control of diuresis and natriuresis and suggest that use of drugs affecting prostaglandin synthesis should be avoided in patients who are undergoing surgery.

Translated title of the contributionImpairment of diuresis in surgical intervention. Role of urinary prostaglandins
Original languageItalian
Pages (from-to)101-104
Number of pages4
JournalMinerva Anestesiologica
Volume56
Issue number4
Publication statusPublished - Apr 1990

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Fingerprint

Dive into the research topics of 'Impairment of diuresis in surgical intervention. Role of urinary prostaglandins'. Together they form a unique fingerprint.

Cite this