Impairment of fibrinolysis after PTCA and restenosis

D. Frisco, M. Capanni, E. Antonucci, L. Chiarugi, R. Marcvcci, A. Farsi, G. Pepe, D. Poli, G. F. Gensini

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Abstract

Percutaneous transluminal coronary angioplasty (PTCA) is still affected by restenosis in rate of 25-40%. This study was aimed to investigate the acute effect of PTCA on clotting activation and fibrinolytic system and the possible role of modifications of haemostasis in relation to restenosis after PTCA. In 83 selected patients, undergoing PTCA blood clotting and fibrinolytic activation were assayed before and within 60 minutes after the procedure. All patients were on acetilsalycilic acid (ASA) and on standard antianginal treament; during the procedure 0.5 g ASA and 10.000 IU heparin i.v. were infused in all patients. Patients were clinically followed up for a mean time of 20 months and angiography was again performed in those who suffered from recurrent anginal attacks or had a positive ergometric test. At the end of the procedure there was a significant decrease in plasma levels of fibrinogen, fragment 1+2 of prothrombin, thrombinantithrombin complexes (p <0.0001), plasminogen activator inhibitor I (PAI-1), tissue-type plasminogen activator antigen (t-PA) and euglobulin lysis time (ELT). D-dimer had a significant increase (p

Original languageEnglish
Pages (from-to)55
Number of pages1
JournalFibrinolysis and Proteolysis
Volume12
Issue numberSUPPL. 1
Publication statusPublished - 1998

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ASJC Scopus subject areas

  • Hematology

Cite this

Frisco, D., Capanni, M., Antonucci, E., Chiarugi, L., Marcvcci, R., Farsi, A., Pepe, G., Poli, D., & Gensini, G. F. (1998). Impairment of fibrinolysis after PTCA and restenosis. Fibrinolysis and Proteolysis, 12(SUPPL. 1), 55.