Impairment of GH secretion in adults with primary empty sella

Maurizio Gasperi; G. Aimaretti; E. Cecconi; A. Colao; C. Di Somma; S. Cannavò; C. Baffoni; M. Cosottini; L. Curtò; F. Trimarchi; G. Lombardi; L. Grasso; E. Ghigo; E. Martino

Impairment of GH secretion in adults with primary empty sella

Maurizio Gasperi, G. Aimaretti, E. Cecconi, A. Colao, C. Di Somma, S. Cannavò, C. Baffoni, M. Cosottini, L. Curtò, F. Trimarchi, G. Lombardi, L. Grasso, E. Ghigo, E. Martino

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Abstract

Primary empty sella (PES) is generally not associated with overt endocrine abnormalities, although mild hyperprolactinemia and, in children, deficient GH secretion have been reported. The aim of this multi-center collaborative study was to evaluate basal and stimulated GH secretion in a large series of adult PES patients. The study group consisted of 51 patients [41 women and 10 men, age range: 20-78 yr; (mean±SD) 47±11 yr]; results were compared with those in normal subjects (Ns) (Ns: no.=110, 55 women, age: 20-50 yr, 37±14 yr), and in hypopituitaric patients (HYP) with GH deficiency (HYP: no.=44, 17 women, age: 20-72, 49±16 yr). Baseline IGF-I levels and GH responses to insulin-induced hypoglycemia (insulin tolerance test, ITT) and/or GHRH+arginine (ARG) stimulation tests were evaluated. PES patients were also subdivided according to BMI in lean (BMI 2 no.=22) or obese (BMI >28 kg/m² no.=29). PES patients had serum total IGF-I concentrations (mean±SE: 142.2±9.6 ng/ml) higher than HYP patients (77.4±6.4 ng/ml, p

Original language	English
Pages (from-to)	329-333
Number of pages	5
Journal	Journal of Endocrinological Investigation
Volume	25
Issue number	4
Publication status	Published - 2002

Keywords

Adult GH deficiency
Empty sella
GH
GHRH+arginine
IGF-I
ITT
Obesity

ASJC Scopus subject areas

Endocrinology

Cite this

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title = "Impairment of GH secretion in adults with primary empty sella",

abstract = "Primary empty sella (PES) is generally not associated with overt endocrine abnormalities, although mild hyperprolactinemia and, in children, deficient GH secretion have been reported. The aim of this multi-center collaborative study was to evaluate basal and stimulated GH secretion in a large series of adult PES patients. The study group consisted of 51 patients [41 women and 10 men, age range: 20-78 yr; (mean±SD) 47±11 yr]; results were compared with those in normal subjects (Ns) (Ns: no.=110, 55 women, age: 20-50 yr, 37±14 yr), and in hypopituitaric patients (HYP) with GH deficiency (HYP: no.=44, 17 women, age: 20-72, 49±16 yr). Baseline IGF-I levels and GH responses to insulin-induced hypoglycemia (insulin tolerance test, ITT) and/or GHRH+arginine (ARG) stimulation tests were evaluated. PES patients were also subdivided according to BMI in lean (BMI 2 no.=22) or obese (BMI >28 kg/m2 no.=29). PES patients had serum total IGF-I concentrations (mean±SE: 142.2±9.6 ng/ml) higher than HYP patients (77.4±6.4 ng/ml, p",

keywords = "Adult GH deficiency, Empty sella, GH, GHRH+arginine, IGF-I, ITT, Obesity",

author = "Maurizio Gasperi and G. Aimaretti and E. Cecconi and A. Colao and {Di Somma}, C. and S. Cannav{\`o} and C. Baffoni and M. Cosottini and L. Curt{\`o} and F. Trimarchi and G. Lombardi and L. Grasso and E. Ghigo and E. Martino",

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AU - Gasperi, Maurizio

AU - Aimaretti, G.

AU - Cecconi, E.

AU - Colao, A.

AU - Di Somma, C.

AU - Cannavò, S.

AU - Baffoni, C.

AU - Cosottini, M.

AU - Curtò, L.

AU - Trimarchi, F.

AU - Lombardi, G.

AU - Grasso, L.

AU - Ghigo, E.

AU - Martino, E.

PY - 2002

Y1 - 2002

N2 - Primary empty sella (PES) is generally not associated with overt endocrine abnormalities, although mild hyperprolactinemia and, in children, deficient GH secretion have been reported. The aim of this multi-center collaborative study was to evaluate basal and stimulated GH secretion in a large series of adult PES patients. The study group consisted of 51 patients [41 women and 10 men, age range: 20-78 yr; (mean±SD) 47±11 yr]; results were compared with those in normal subjects (Ns) (Ns: no.=110, 55 women, age: 20-50 yr, 37±14 yr), and in hypopituitaric patients (HYP) with GH deficiency (HYP: no.=44, 17 women, age: 20-72, 49±16 yr). Baseline IGF-I levels and GH responses to insulin-induced hypoglycemia (insulin tolerance test, ITT) and/or GHRH+arginine (ARG) stimulation tests were evaluated. PES patients were also subdivided according to BMI in lean (BMI 2 no.=22) or obese (BMI >28 kg/m2 no.=29). PES patients had serum total IGF-I concentrations (mean±SE: 142.2±9.6 ng/ml) higher than HYP patients (77.4±6.4 ng/ml, p

AB - Primary empty sella (PES) is generally not associated with overt endocrine abnormalities, although mild hyperprolactinemia and, in children, deficient GH secretion have been reported. The aim of this multi-center collaborative study was to evaluate basal and stimulated GH secretion in a large series of adult PES patients. The study group consisted of 51 patients [41 women and 10 men, age range: 20-78 yr; (mean±SD) 47±11 yr]; results were compared with those in normal subjects (Ns) (Ns: no.=110, 55 women, age: 20-50 yr, 37±14 yr), and in hypopituitaric patients (HYP) with GH deficiency (HYP: no.=44, 17 women, age: 20-72, 49±16 yr). Baseline IGF-I levels and GH responses to insulin-induced hypoglycemia (insulin tolerance test, ITT) and/or GHRH+arginine (ARG) stimulation tests were evaluated. PES patients were also subdivided according to BMI in lean (BMI 2 no.=22) or obese (BMI >28 kg/m2 no.=29). PES patients had serum total IGF-I concentrations (mean±SE: 142.2±9.6 ng/ml) higher than HYP patients (77.4±6.4 ng/ml, p

KW - Adult GH deficiency

KW - Empty sella

KW - GH

KW - GHRH+arginine

KW - IGF-I

KW - ITT

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Impairment of GH secretion in adults with primary empty sella

Abstract

Keywords

ASJC Scopus subject areas

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