Impairment of GH secretion in adults with primary empty sella

Maurizio Gasperi, G. Aimaretti, E. Cecconi, A. Colao, C. Di Somma, S. Cannavò, C. Baffoni, M. Cosottini, L. Curtò, F. Trimarchi, G. Lombardi, L. Grasso, E. Ghigo, E. Martino

Research output: Contribution to journalArticlepeer-review


Primary empty sella (PES) is generally not associated with overt endocrine abnormalities, although mild hyperprolactinemia and, in children, deficient GH secretion have been reported. The aim of this multi-center collaborative study was to evaluate basal and stimulated GH secretion in a large series of adult PES patients. The study group consisted of 51 patients [41 women and 10 men, age range: 20-78 yr; (mean±SD) 47±11 yr]; results were compared with those in normal subjects (Ns) (Ns: no.=110, 55 women, age: 20-50 yr, 37±14 yr), and in hypopituitaric patients (HYP) with GH deficiency (HYP: no.=44, 17 women, age: 20-72, 49±16 yr). Baseline IGF-I levels and GH responses to insulin-induced hypoglycemia (insulin tolerance test, ITT) and/or GHRH+arginine (ARG) stimulation tests were evaluated. PES patients were also subdivided according to BMI in lean (BMI 2 no.=22) or obese (BMI >28 kg/m2 no.=29). PES patients had serum total IGF-I concentrations (mean±SE: 142.2±9.6 ng/ml) higher than HYP patients (77.4±6.4 ng/ml, p

Original languageEnglish
Pages (from-to)329-333
Number of pages5
JournalJournal of Endocrinological Investigation
Issue number4
Publication statusPublished - 2002


  • Adult GH deficiency
  • Empty sella
  • GH
  • GHRH+arginine
  • IGF-I
  • ITT
  • Obesity

ASJC Scopus subject areas

  • Endocrinology


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