Impairment of GH secretion in adults with primary empty sella

Maurizio Gasperi; G. Aimaretti; E. Cecconi; A. Colao; C. Di Somma; S. Cannavò; C. Baffoni; M. Cosottini; L. Curtò; F. Trimarchi; G. Lombardi; L. Grasso; E. Ghigo; E. Martino

Impairment of GH secretion in adults with primary empty sella

Maurizio Gasperi, G. Aimaretti, E. Cecconi, A. Colao, C. Di Somma, S. Cannavò, C. Baffoni, M. Cosottini, L. Curtò, F. Trimarchi, G. Lombardi, L. Grasso, E. Ghigo, E. Martino

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Research output: Contribution to journal › Article

Abstract

Primary empty sella (PES) is generally not associated with overt endocrine abnormalities, although mild hyperprolactinemia and, in children, deficient GH secretion have been reported. The aim of this multi-center collaborative study was to evaluate basal and stimulated GH secretion in a large series of adult PES patients. The study group consisted of 51 patients [41 women and 10 men, age range: 20-78 yr; (mean±SD) 47±11 yr]; results were compared with those in normal subjects (Ns) (Ns: no.=110, 55 women, age: 20-50 yr, 37±14 yr), and in hypopituitaric patients (HYP) with GH deficiency (HYP: no.=44, 17 women, age: 20-72, 49±16 yr). Baseline IGF-I levels and GH responses to insulin-induced hypoglycemia (insulin tolerance test, ITT) and/or GHRH+arginine (ARG) stimulation tests were evaluated. PES patients were also subdivided according to BMI in lean (BMI 2 no.=22) or obese (BMI >28 kg/m² no.=29). PES patients had serum total IGF-I concentrations (mean±SE: 142.2±9.6 ng/ml) higher than HYP patients (77.4±6.4 ng/ml, p

Original language	English
Pages (from-to)	329-333
Number of pages	5
Journal	Journal of Endocrinological Investigation
Volume	25
Issue number	4
Publication status	Published - 2002

Keywords

Adult GH deficiency
Empty sella
GH
GHRH+arginine
IGF-I
ITT
Obesity

ASJC Scopus subject areas

Endocrinology

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Gasperi, M., Aimaretti, G., Cecconi, E., Colao, A., Di Somma, C., Cannavò, S., Baffoni, C., Cosottini, M., Curtò, L., Trimarchi, F., Lombardi, G., Grasso, L., Ghigo, E., & Martino, E. (2002). Impairment of GH secretion in adults with primary empty sella. Journal of Endocrinological Investigation, 25(4), 329-333.

Impairment of GH secretion in adults with primary empty sella. / Gasperi, Maurizio; Aimaretti, G.; Cecconi, E.; Colao, A.; Di Somma, C.; Cannavò, S.; Baffoni, C.; Cosottini, M.; Curtò, L.; Trimarchi, F.; Lombardi, G.; Grasso, L.; Ghigo, E.; Martino, E.

In: Journal of Endocrinological Investigation, Vol. 25, No. 4, 2002, p. 329-333.

Research output: Contribution to journal › Article

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AU - Baffoni, C.

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