Impairment of in vitro natural antibacterial activity in HIV-infected patients

A. Tagliabue, L. Nencioni, A. Mantovani, A. Lazzarin, L. Villa, M. Romano, S. Rossini, C. U. Foppa, G. Fanetti, L. C. Masello, G. Poli

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Circulating PBMC of healthy subjects possess an in vitro natural antibacterial (NA) against entero-pathogenic bacteria, including Salmonella species. The effector cell of NA activity is a CD: 4+, 8-, Leu-8/TQ-1+ T lymphocyte acting against bacteria via cytophylic IgA in a mechanism similar to antibody-dependent cellular activity. Because AIDS is a profound immunodeficiency caused by HIV involving primarily CD4 lymphocytes and in particular the Leu-8/TQ-1 subset, it was of interest to assess NA activity of HIV+ subjects at various stages of the disease. Results indicate that NA activity against Salmonella typhi and Salmonella paratyphi C is significantly decreased in AIDS as well as in lymph-adenopathy syndrome patients. Furthermore, sera containing IgA against salmonellae were not able to arm PBMC from HIV+ patients. The humoral response against S. typhi-LPS was also greatly decreased after HIV infection, in contrast to the known hypergammaglobulinemia seen in these subjects. Defective NA activity might contribute to the increased incidence of salmonellosis observed in AIDS.

Original languageEnglish
Pages (from-to)2607-2611
Number of pages5
JournalJournal of Immunology
Issue number8
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Immunology


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