Impairment of neuromuscular transmission in a subgroup of migraine patients

Anna Ambrosini, Alain Maertens De Noordhout, Giovanna Alagona, Francesca Dalpozzo, Jean Schoenen

Research output: Contribution to journalArticle

Abstract

Neuronal voltage-dependent P/Q Ca2+ channels are genetically abnormal in many cases of familial hemiplegic migraine and possibly associated with the more common forms of migraine with and without aura. Besides the brain, these channels are found in motor nerve endings where they control stimulation-induced acetylcholine release. Using single fiber EMG recordings we were able to demonstrate subclinical abnormalities of neuromuscular transmission in a subgroup of patients suffering from migraine with aura. This could be related to genetic abnormalities of P/Q Ca2+ channels in certain patients suffering from migraine with aura, which needs to be explored by proper genetic analyses. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)201-203
Number of pages3
JournalNeuroscience Letters
Volume276
Issue number3
DOIs
Publication statusPublished - Dec 10 1999

Keywords

  • Familial hemiplegic migraine
  • Migraine
  • Neuromuscular transmission
  • P/Q Ca channels
  • Single fiber electromyography

ASJC Scopus subject areas

  • Neuroscience(all)

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