Impairment of primary haemostasis by low molecular weight heparins in rats

A. Borowska, D. Lauri, A. Maggi, E. Dejana, G. De Gaetano, M. B. Donati, J. Pangrazzi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Different low molecular weight (LMW) heparins were tested on primary haemostasis in rats. Four preparations were studied; one was devoid of any effect on the bleeding time, while the other three prolonged the bleeding time to varying extents. As a consequence we studied the effect of these heparins on platelet aggregation. The fractions which prolonged the bleeding time, also inhibited the ex vivo and in vitro platelet aggregation, whereas the one devoid of any effect on the bleeding time did not affect platelet aggregation. Similar results were obtained using both platelet-rich plasma (PRP) and gel-filtered platelets. The in vitro response of platelets to aggregating agents may offer a parameter to detect the presence of 'bleeding factor(s)' in some LMW heparin preparations.

Original languageEnglish
Pages (from-to)339-344
Number of pages6
JournalBritish Journal of Haematology
Volume68
Issue number3
Publication statusPublished - 1988

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Bleeding Time
Low Molecular Weight Heparin
Hemostasis
Platelet Aggregation
Blood Platelets
Platelet-Rich Plasma
Heparin
Gels
Hemorrhage
In Vitro Techniques

ASJC Scopus subject areas

  • Hematology

Cite this

Borowska, A., Lauri, D., Maggi, A., Dejana, E., De Gaetano, G., Donati, M. B., & Pangrazzi, J. (1988). Impairment of primary haemostasis by low molecular weight heparins in rats. British Journal of Haematology, 68(3), 339-344.

Impairment of primary haemostasis by low molecular weight heparins in rats. / Borowska, A.; Lauri, D.; Maggi, A.; Dejana, E.; De Gaetano, G.; Donati, M. B.; Pangrazzi, J.

In: British Journal of Haematology, Vol. 68, No. 3, 1988, p. 339-344.

Research output: Contribution to journalArticle

Borowska, A, Lauri, D, Maggi, A, Dejana, E, De Gaetano, G, Donati, MB & Pangrazzi, J 1988, 'Impairment of primary haemostasis by low molecular weight heparins in rats', British Journal of Haematology, vol. 68, no. 3, pp. 339-344.
Borowska, A. ; Lauri, D. ; Maggi, A. ; Dejana, E. ; De Gaetano, G. ; Donati, M. B. ; Pangrazzi, J. / Impairment of primary haemostasis by low molecular weight heparins in rats. In: British Journal of Haematology. 1988 ; Vol. 68, No. 3. pp. 339-344.
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