TY - JOUR
T1 - Impairment of thermoregulatory control of skin sympathetic nerve traffic in the elderly
AU - Grassi, Guido
AU - Seravalle, Gino
AU - Turri, Carlo
AU - Bertinieri, Giovanni
AU - Dell'Oro, Raffaella
AU - Mancia, Giuseppe
PY - 2003/8/12
Y1 - 2003/8/12
N2 - Background - Human aging is characterized by a marked increase in muscle sympathetic nerve traffic (MSNA). No information exists, however, on the effects of aging on skin sympathetic nerve traffic (SSNA) and on its reflex modulation by thermoregulatory mechanisms. Methods and Results - In 13 young, 11 middle-aged, and 12 elderly healthy subjects, we measured arterial blood pressure (Finapres), skin temperature (thermocouples), and resting MSNA and SSNA (microneurography). Measurements also included the SSNA responses to (1) an acute increase and reduction (±8°C) in room temperature, each lasting 45 minutes and (2) an acoustic stimulus capable to trigger an emotional arousal. Although resting MSNA was progressively and significantly (P
AB - Background - Human aging is characterized by a marked increase in muscle sympathetic nerve traffic (MSNA). No information exists, however, on the effects of aging on skin sympathetic nerve traffic (SSNA) and on its reflex modulation by thermoregulatory mechanisms. Methods and Results - In 13 young, 11 middle-aged, and 12 elderly healthy subjects, we measured arterial blood pressure (Finapres), skin temperature (thermocouples), and resting MSNA and SSNA (microneurography). Measurements also included the SSNA responses to (1) an acute increase and reduction (±8°C) in room temperature, each lasting 45 minutes and (2) an acoustic stimulus capable to trigger an emotional arousal. Although resting MSNA was progressively and significantly (P
KW - Aging
KW - Nervous system
KW - Nervous system, sympathetic
KW - Reflex
UR - http://www.scopus.com/inward/record.url?scp=0042162993&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0042162993&partnerID=8YFLogxK
U2 - 10.1161/01.CIR.0000081769.02847.A1
DO - 10.1161/01.CIR.0000081769.02847.A1
M3 - Article
C2 - 12885757
AN - SCOPUS:0042162993
VL - 108
SP - 729
EP - 735
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 6
ER -