Impairment of thermoregulatory control of skin sympathetic nerve traffic in the elderly

Guido Grassi; Gino Seravalle; Carlo Turri; Giovanni Bertinieri; Raffaella Dell'Oro; Giuseppe Mancia

doi:10.1161/01.CIR.0000081769.02847.A1

Impairment of thermoregulatory control of skin sympathetic nerve traffic in the elderly

Guido Grassi, Gino Seravalle, Carlo Turri, Giovanni Bertinieri, Raffaella Dell'Oro, Giuseppe Mancia

Research output: Contribution to journal › Article › peer-review

Abstract

Background - Human aging is characterized by a marked increase in muscle sympathetic nerve traffic (MSNA). No information exists, however, on the effects of aging on skin sympathetic nerve traffic (SSNA) and on its reflex modulation by thermoregulatory mechanisms. Methods and Results - In 13 young, 11 middle-aged, and 12 elderly healthy subjects, we measured arterial blood pressure (Finapres), skin temperature (thermocouples), and resting MSNA and SSNA (microneurography). Measurements also included the SSNA responses to (1) an acute increase and reduction (±8°C) in room temperature, each lasting 45 minutes and (2) an acoustic stimulus capable to trigger an emotional arousal. Although resting MSNA was progressively and significantly (P

Original language	English
Pages (from-to)	729-735
Number of pages	7
Journal	Circulation
Volume	108
Issue number	6
DOIs	https://doi.org/10.1161/01.CIR.0000081769.02847.A1
Publication status	Published - Aug 12 2003

Keywords

Aging
Nervous system
Nervous system, sympathetic
Reflex

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

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abstract = "Background - Human aging is characterized by a marked increase in muscle sympathetic nerve traffic (MSNA). No information exists, however, on the effects of aging on skin sympathetic nerve traffic (SSNA) and on its reflex modulation by thermoregulatory mechanisms. Methods and Results - In 13 young, 11 middle-aged, and 12 elderly healthy subjects, we measured arterial blood pressure (Finapres), skin temperature (thermocouples), and resting MSNA and SSNA (microneurography). Measurements also included the SSNA responses to (1) an acute increase and reduction (±8°C) in room temperature, each lasting 45 minutes and (2) an acoustic stimulus capable to trigger an emotional arousal. Although resting MSNA was progressively and significantly (P",

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AU - Grassi, Guido

AU - Seravalle, Gino

AU - Turri, Carlo

AU - Bertinieri, Giovanni

AU - Dell'Oro, Raffaella

AU - Mancia, Giuseppe

PY - 2003/8/12

Y1 - 2003/8/12

N2 - Background - Human aging is characterized by a marked increase in muscle sympathetic nerve traffic (MSNA). No information exists, however, on the effects of aging on skin sympathetic nerve traffic (SSNA) and on its reflex modulation by thermoregulatory mechanisms. Methods and Results - In 13 young, 11 middle-aged, and 12 elderly healthy subjects, we measured arterial blood pressure (Finapres), skin temperature (thermocouples), and resting MSNA and SSNA (microneurography). Measurements also included the SSNA responses to (1) an acute increase and reduction (±8°C) in room temperature, each lasting 45 minutes and (2) an acoustic stimulus capable to trigger an emotional arousal. Although resting MSNA was progressively and significantly (P

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