Impairments of synaptic plasticity in aged animals and in animal models of Alzheimer's disease

Marta Balietti, Francesco Tamagnini, Patrizia Fattoretti, Costanza Burattini, Tiziana Casoli, Daniela Platano, Fabrizia Lattanzio, Giorgio Aicardi

Research output: Contribution to journalArticle

Abstract

Aging is associated with a gradual decline in cognitive functions, and more dramatic cognitive impairments occur in patients affected by Alzheimer's disease (AD). Electrophysiological and molecular studies performed in aged animals and in animal models of AD have shown that cognitive decline is associated with significant modifications in synaptic plasticity (i.e., activity-dependent changes in synaptic strength) and have elucidated some of the cellular mechanisms underlying this process. Morphological studies have revealed a correlation between the quality of memory performance and the extent of structural changes of synaptic contacts occurring during memory consolidation. We briefly review recent experimental evidence here.

Original languageEnglish
Pages (from-to)235-238
Number of pages4
JournalRejuvenation Research
Volume15
Issue number2
DOIs
Publication statusPublished - Apr 1 2012

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

Fingerprint Dive into the research topics of 'Impairments of synaptic plasticity in aged animals and in animal models of Alzheimer's disease'. Together they form a unique fingerprint.

  • Cite this