Implantable Cardioverter-Defibrillator Therapy for Prevention of Sudden Death in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia

Domenico Corrado, Loira Leoni, Mark S. Link, Paolo Della Bella, Fiorenzo Gaita, Antonio Curnis, Jorge Uriarte Salerno, Diran Igidbashian, Antonio Raviele, Marcello Disertori, Gabriele Zanotto, Roberto Verlato, Giuseppe Vergara, Pietro Delise, Pietro Turrini, Cristina Basso, Franco Naccarella, Francesco Maddalena, N. A Mark Estes, Gianfranco BujaGaetano Thiene

Research output: Contribution to journalArticlepeer-review

Abstract

Background-Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a condition associated with the risk of sudden death (SD). Methods and Results-We conducted a multicenter study of the impact of the implantable cardioverter-defibrillator (ICD) for prevention of SD in 132 patients (93 males and 39 females, age 40±15 years) with ARVC/D. Implant indications were a history of cardiac arrest in 13 patients (10%), sustained ventricular tachycardia in 82 (62%), syncope in 21 (16%), and other in 16 (12%). During a mean follow-up of 39±25 months, 64 patients (48%) had appropriate ICD interventions, 21 (16%) had inappropriate interventions, and 19 (14%) had ICD-related complications. Fifty-three (83%) of the 64 patients with appropriate interventions received antiarrhythmic drug therapy at the time of first ICD discharge. Programmed ventricular stimulation was of limited value in identifying patients at risk of tachyarrhythmias during the follow-up (positive predictive value 49%, negative predictive value 54%). Four patients (3%) died, and 32 (24%) experienced ventricular fibrillation/flutter that in all likelihood would have been fatal in the absence of the device. At 36 months, the actual patient survival rate was 96% compared with the ventricular fibrillation/flutter-free survival rate of 72% (P

Original languageEnglish
Pages (from-to)3084-3091
Number of pages8
JournalCirculation
Volume108
Issue number25
DOIs
Publication statusPublished - Dec 23 2003

Keywords

  • Cardiomyopathy
  • Death, sudden
  • Defibrillation
  • Prevention
  • Tachyarrhythmias

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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