Implants of heterologous demineralized bone matrix for induction of posterior spinal fusion in rats

Stefano Guizzardi, Renato Scandroglio, Mario Di Silvestre, Romolo Savini, Alessandro Ruggeri

Research output: Contribution to journalArticlepeer-review

Abstract

The authors tested the osteoinductivo capacity of powdered heterologous (bovine) damlnerailied bone matrix in rets. The first pert of the study concerned a mono lateral posterior spinal Implant after dKorticatron ul three vertabrae, using as a control area the animal's contralateral sidB, in which neither bDno graft nor any other malarial were placed. In another group of rats, a comparative evaluation was made of powdered hetorologous demineralizad bone matrix and fresh autologous bone. In the same animal, autologous bone was implanted to realize a thoracic posterior fusion and demlnarallzed bora matrix, to Induce a posterior fusion in tin a:umbar area. Alt data obtained suggested a good ostcoinductive activity of hetarologous powdered demineralized bone matrix. The two posterior spinal fusions done in the same animal with heterologous dsmineralizad bone matrix or autologous bone, respectively, had similar callus development and required the same time for formation.

Original languageEnglish
Pages (from-to)701-707
Number of pages7
JournalSpine
Volume17
Issue number6
Publication statusPublished - 1992

Keywords

  • Demineralized bone matrix
  • Spinal fusion

ASJC Scopus subject areas

  • Clinical Neurology
  • Orthopedics and Sports Medicine
  • Physiology

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