Implementation of a molecular epidemiology approach to human pleural malignant mesothelioma

Riccardo Puntoni, Rosangela Filiberti, Paolo G. Cerrano, Monica Neri, Rossana Andreatta, Stefano Bonassi

Research output: Contribution to journalArticlepeer-review

Abstract

The carcinogenic effect of asbestos has been reported in the literature since 40 years, and early studies describing the epidemic occurrence of malignant mesothelioma (MM) in asbestos workers, have become a paradigm of occupational cancer research. Research on MM was abandoned for many years since MM was considered as an asbestos-related disease, interesting only from a perspective of disease control and preventive policies. The introduction of new biological endpoints in the epidemiological studies has boosted research in the field, providing new tools for the study of emerging priority in cancer research and in public health. This approach, known as molecular epidemiology has a great potential in the study of MM, contributing to the understanding of susceptibility factors, to the evaluation of cancer risk in people occupationally or environmentally exposed to carcinogens, and to the enhancement of diagnosis and therapy. A comprehensive approach based on the use of banks of biological samples is presented and its advantages discussed here. The application of innovative endpoints, such as oncoproteins in biologic fluids, genetic polimorphisms, or gene function is discussed, and relevant literature reviewed.

Original languageEnglish
Pages (from-to)385-396
Number of pages12
JournalMutation Research - Reviews in Mutation Research
Volume544
Issue number2-3
DOIs
Publication statusPublished - Nov 2003

Keywords

  • DNA repair
  • Individual susceptibility
  • Malignant mesothelioma
  • Metabolic polymorphisms
  • Molecular epidemiology

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis

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