Abstract
Background: Frailty is a state of increased vulnerability to stressors, associated to poor health outcomes. The aim of this study was to design and introduce a Frailty Index (FI; according to the age-related accumulation of deficit model) in a large cohort of hospitalized older persons, in order to benefit from its capacity to comprehensively weight the risk profile of the individual. Methods: Patients aged 65 and older enrolled in the REPOSI register from 2010 to 2016 were considered in the present analyses. Variables recorded at the hospital admission (including socio-demographic, physical, cognitive, functional and clinical factors) were used to compute the FI. The prognostic impact of the FI on in-hospital and 12-month mortality was assessed. Results: Among the 4488 patients of the REPOSI register, 3847 were considered eligible for a 34-item FI computation. The median FI in the sample was 0.27 (interquartile range 0.21–0.37). The FI was significantly predictive of both in-hospital (OR 1.61, 95%CI 1.38–1.87) and overall (HR 1.46, 95%CI 1.32–1.62) mortality, also after adjustment for age and sex. Conclusions: The FI confirms its strong predictive value for negative outcomes. Its implementation in cohort studies (including those conducted in the hospital setting) may provide useful information for better weighting the complexity of the older person and accordingly design personalized interventions.
| Original language | English |
|---|---|
| Pages (from-to) | 11-18 |
| Journal | European Journal of Internal Medicine |
| Volume | 56 |
| DOIs | |
| Publication status | Published - 2018 |
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Keywords
- Frailty
- Internal medicine and geriatric wards
- Multimorbidity
- Physical and cognitive impairment
ASJC Scopus subject areas
- Internal Medicine
Cite this
Implementation of the Frailty Index in hospitalized older patients : Results from the REPOSI register. / the REPOSI collaborators.
In: European Journal of Internal Medicine, Vol. 56, 2018, p. 11-18.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Implementation of the Frailty Index in hospitalized older patients
T2 - Results from the REPOSI register
AU - the REPOSI collaborators
AU - Cesari, M.
AU - Franchi, C.
AU - Cortesi, L.
AU - Nobili, A.
AU - Ardoino, I.
AU - Mannucci, P. M.
PY - 2018
Y1 - 2018
N2 - Background: Frailty is a state of increased vulnerability to stressors, associated to poor health outcomes. The aim of this study was to design and introduce a Frailty Index (FI; according to the age-related accumulation of deficit model) in a large cohort of hospitalized older persons, in order to benefit from its capacity to comprehensively weight the risk profile of the individual. Methods: Patients aged 65 and older enrolled in the REPOSI register from 2010 to 2016 were considered in the present analyses. Variables recorded at the hospital admission (including socio-demographic, physical, cognitive, functional and clinical factors) were used to compute the FI. The prognostic impact of the FI on in-hospital and 12-month mortality was assessed. Results: Among the 4488 patients of the REPOSI register, 3847 were considered eligible for a 34-item FI computation. The median FI in the sample was 0.27 (interquartile range 0.21–0.37). The FI was significantly predictive of both in-hospital (OR 1.61, 95%CI 1.38–1.87) and overall (HR 1.46, 95%CI 1.32–1.62) mortality, also after adjustment for age and sex. Conclusions: The FI confirms its strong predictive value for negative outcomes. Its implementation in cohort studies (including those conducted in the hospital setting) may provide useful information for better weighting the complexity of the older person and accordingly design personalized interventions.
AB - Background: Frailty is a state of increased vulnerability to stressors, associated to poor health outcomes. The aim of this study was to design and introduce a Frailty Index (FI; according to the age-related accumulation of deficit model) in a large cohort of hospitalized older persons, in order to benefit from its capacity to comprehensively weight the risk profile of the individual. Methods: Patients aged 65 and older enrolled in the REPOSI register from 2010 to 2016 were considered in the present analyses. Variables recorded at the hospital admission (including socio-demographic, physical, cognitive, functional and clinical factors) were used to compute the FI. The prognostic impact of the FI on in-hospital and 12-month mortality was assessed. Results: Among the 4488 patients of the REPOSI register, 3847 were considered eligible for a 34-item FI computation. The median FI in the sample was 0.27 (interquartile range 0.21–0.37). The FI was significantly predictive of both in-hospital (OR 1.61, 95%CI 1.38–1.87) and overall (HR 1.46, 95%CI 1.32–1.62) mortality, also after adjustment for age and sex. Conclusions: The FI confirms its strong predictive value for negative outcomes. Its implementation in cohort studies (including those conducted in the hospital setting) may provide useful information for better weighting the complexity of the older person and accordingly design personalized interventions.
KW - Frailty
KW - Internal medicine and geriatric wards
KW - Multimorbidity
KW - Physical and cognitive impairment
UR - http://www.scopus.com/inward/record.url?scp=85048350342&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85048350342&partnerID=8YFLogxK
U2 - 10.1016/j.ejim.2018.06.001
DO - 10.1016/j.ejim.2018.06.001
M3 - Article
AN - SCOPUS:85048350342
VL - 56
SP - 11
EP - 18
JO - European Journal of Internal Medicine
JF - European Journal of Internal Medicine
SN - 0953-6205
ER -