TY - JOUR
T1 - Implication of aging related chronic neuroinflammation on covid-19 pandemic
AU - Bossù, Paola
AU - Toppi, Elisa
AU - Sterbini, Valentina
AU - Spalletta, Gianfranco
N1 - Funding Information:
Figure 2. Potential impact of chronic neuroinflammation on COVID-19 severity: a detailed of the drawing is reported in the text. CNS: Central Nervous System. explanation of the drawing is reported in the text. CNS: Central Nervous System Author Contributions: All authors contributed substantially to the work reported. Conceptualization, P.B. and and G.S.; writing—original draft preparation, P.B.; writing—review and editing, P.B., G.S., E.T., V.S.; funding G.S.; writing—original draft preparation, P.B.; writing—review and editing, P.B., G.S., E.T., V.S.; funding acquisition, P.B. and G.S. All authors have read and agreed to the published version of the manuscript. acquisition, P.B. and G.S. All authors have read and agreed to the published version of the manuscript. Funding: This study was funded by Italian Ministry of Health, grant number RC19A; RC20A. Funding: This study was funded by Italian Ministry of Health, grant number RC19A; RC20A. Conflicts of Interest: The authors declare no conflict of interest. Conflicts of Interest: The authors declare no conflict of interest.
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/9
Y1 - 2020/9
N2 - SARS-CoV-2, the virus responsible for the COVID-19 pandemic, leads to a respiratory syndrome and other manifestations. Most affected people show no or mild symptoms, but the risk of severe disease and death increases in older people. Here, we report a narrative review on selected studies targeting aging-related chronic neuroinflammation in the COVID-19 pandemic. A hyperactivation of the innate immune system with elevated levels of pro-inflammatory cytokines occurs during severe COVID-19, pointing to an important role of the innate immune dysregulation in the disease outcome. Aging is characterized by a general condition of low-grade inflammation, also connected to chronic inflammation of the brain (neuroinflammation), which is involved in frailty syndrome and contributes to several age-associated diseases, including neurodegenerative and neuropsychiatric disorders. Since neuroinflammation can be induced or worsened by the virus infection itself, as well as by stressful conditions like those linked to the recent pandemic, the role of neuroinflammatory mechanisms could be central in a vicious circle leading to an increase in the mortality risk in aged COVID-19 patients. Furthermore, triggered neuroinflammatory pathways and consequent neurodegenerative and neuropsychiatric conditions might be potential long-term complications of COVID-19. In order to provide insights to help clinicians in identifying patients who progress to a more severe case of the disease, this review underlines the potential implications of aging-related neuroinflammation in COVID-19 pandemic.
AB - SARS-CoV-2, the virus responsible for the COVID-19 pandemic, leads to a respiratory syndrome and other manifestations. Most affected people show no or mild symptoms, but the risk of severe disease and death increases in older people. Here, we report a narrative review on selected studies targeting aging-related chronic neuroinflammation in the COVID-19 pandemic. A hyperactivation of the innate immune system with elevated levels of pro-inflammatory cytokines occurs during severe COVID-19, pointing to an important role of the innate immune dysregulation in the disease outcome. Aging is characterized by a general condition of low-grade inflammation, also connected to chronic inflammation of the brain (neuroinflammation), which is involved in frailty syndrome and contributes to several age-associated diseases, including neurodegenerative and neuropsychiatric disorders. Since neuroinflammation can be induced or worsened by the virus infection itself, as well as by stressful conditions like those linked to the recent pandemic, the role of neuroinflammatory mechanisms could be central in a vicious circle leading to an increase in the mortality risk in aged COVID-19 patients. Furthermore, triggered neuroinflammatory pathways and consequent neurodegenerative and neuropsychiatric conditions might be potential long-term complications of COVID-19. In order to provide insights to help clinicians in identifying patients who progress to a more severe case of the disease, this review underlines the potential implications of aging-related neuroinflammation in COVID-19 pandemic.
KW - Brain inflammation
KW - COVID-19 neurological and psychiatric manifestations
KW - Elderly
KW - SARS-CoV-2
KW - Severe COVID-19
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U2 - 10.3390/jpm10030102
DO - 10.3390/jpm10030102
M3 - Review article
AN - SCOPUS:85089847454
VL - 10
SP - 1
EP - 13
JO - Journal of Personalized Medicine
JF - Journal of Personalized Medicine
SN - 2075-4426
IS - 3
M1 - 102
ER -