Implications for the mammalian sialidases in the physiopathology of skeletal muscle

Alessandro Fanzani, Alessandra Zanola, Fiorella Faggi, Nadia Papini, Bruno Venerando, Guido Tettamanti, Maurilio Sampaolesi, Eugenio Monti

Research output: Contribution to journalArticlepeer-review

Abstract

The family of mammalian sialidases is composed of four distinct versatile enzymes that remove negatively charged terminal sialic acid residues from gangliosides and glycoproteins in different subcellular areas and organelles, including lysosomes, cytosol, plasma membrane and mitochondria. In this review we summarize the growing body of data describing the important role of sialidases in skeletal muscle, a complex apparatus involved in numerous key functions and whose functional integrity can be affected by various conditions, such as aging, chronic diseases, cancer and neuromuscular disorders. In addition to supporting the proper catabolism of glycoconjugates, sialidases can affect different signaling pathways by desialylation of many receptors and modulation of ganglioside content in cell membranes, thus actively participating in myoblast proliferation, differentiation and hypertrophy, insulin responsiveness and skeletal muscle architecture.

Original languageEnglish
Article number23
JournalSkeletal Muscle
Volume2
Issue number1
DOIs
Publication statusPublished - Nov 1 2012

Keywords

  • Gangliosides
  • Glycoproteins
  • Myogenesis
  • Sialidases
  • Skeletal muscle

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology
  • Orthopedics and Sports Medicine

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