Implicazione del polimorfismo +647 A/C del gene MT1A nel diabete mellito di tipo 2

Translated title of the contribution: Implications of +647 A/C MT1A polymorphism in type 2 diabetes

Robertina Giacconi, A. R. Bonfigli, R. Testa, C. Sirolla, C. Cipriano, M. Marra, M. Malavolta, F. Lattanzio, E. Mocchegiani

Research output: Contribution to journalArticlepeer-review


Objectives. Metallothioneins (MT) are zinc-binding proteins which, by means of their antioxidant properties, might prevent the development of diabetic cardiovascular complications. A recent investigation shows that A/C +647 MT1A polymorphism affects the intracellular zinc ion release (iZnR) from MT and is associated with longevity. The aim of the present study is to assess the role of + 647 A/C MT1A polymorphism with the susceptibility to type 2 diabetes (DM2). Materials and methods. The case-control association study included 242 old healthy controls and 235 diabetic patients with a diagnosis of CVD (age > 60 yrs). Results. C allele was more prevalent in patients than in controls (OR = 1.54; p = 0.002). C+ carriers showed higher blood glucose levels and glycosylated hemoglobin. A modulation of MT levels and iZnR were observed in relation to +647A/C MT1A polymorphism. Conclusions. An association between +647 A/C MT1A polymorphism and DM2 was found. Moreover, C+ carriers presented a worse glycemic control and an altered zinc homeostasis, suggesting a possible role of MT in the progression of DM2.

Translated title of the contributionImplications of +647 A/C MT1A polymorphism in type 2 diabetes
Original languageItalian
Pages (from-to)189-193
Number of pages5
JournalGiornale di Gerontologia
Issue number4
Publication statusPublished - Aug 2009

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology


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