Implications of erbB-2 overexpression for basic science and clinical medicine

C. Richter King, Matthias H. Kraus, Pier Paolo DiFiore, Soonmyoung Paik, Philip G. Kasprzyk

Research output: Contribution to journalArticle

Abstract

Overexpression of the Epidermal Growth Factor (EGF) Receptor gene and the related erbB-2 gene has been identified in human cancers derived from a variety of tissues. The overexpression of the encoded growth factor receptor proteins is functionally related to the development of the tumor. This observation has important potential consequences for the improved diagnosis and treatment of cancer. Overexpression of these proteins also provides experimental systems that facilitate the study of growth factor signal transduction.

Original languageEnglish
Pages (from-to)329-337
Number of pages9
JournalSeminars in Cancer Biology
Volume1
Issue number5
Publication statusPublished - Oct 1990

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Keywords

  • Breast cancer
  • Diagnosis
  • EGF receptor
  • erbB-2
  • Therapy

ASJC Scopus subject areas

  • Cancer Research

Cite this

King, C. R., Kraus, M. H., DiFiore, P. P., Paik, S., & Kasprzyk, P. G. (1990). Implications of erbB-2 overexpression for basic science and clinical medicine. Seminars in Cancer Biology, 1(5), 329-337.