Implications of Prostate-Specific Antigen Doubling Time as Indicator of Failure after Surgery or Radiation Therapy for Prostate Cancer{A figure is presented}

Massimo Maffezzini, Alberto Bossi, Laurence Collette

Research output: Contribution to journalArticle

Abstract

Objectives: To review the methodology of PSA doubling time (PSA DT) calculations and the implications of PSA DT for the follow-up of prostate cancer patients curatively treated with surgery or radiation therapy. Methods: A literature search of the most recent articles on PSA DT (those published after 2000) led to the selection of six studies with the largest and best-documented cohorts of patients treated with surgery or irradiation with curative intent. Results: PSA kinetics, in the form of PSA DT, is the most effective parameter for identifying patients at significant risk for mortality specific to prostate cancer. Thresholds of 3, 6, and 12 mo have shown prognostic significance both in surgical and radiation series, notwithstanding differences in treatment selection, definition of biochemical recurrence, and methods of DT calculation. Conclusions: In retrospective studies, PSA DT is a reliable predictor of prognosis; however, prospective validation studies are needed to determine the cut points of PSA DT. Optimal time intervals for calculation and optimal thresholds are still to be determined.

Original languageEnglish
Pages (from-to)605-613
Number of pages9
JournalEuropean Urology
Volume51
Issue number3
DOIs
Publication statusPublished - Mar 2007

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Prostate-Specific Antigen
Prostatic Neoplasms
Radiotherapy
Validation Studies
Retrospective Studies
Prospective Studies
Radiation
Recurrence
Mortality

Keywords

  • Biochemical recurrence
  • Prostate cancer
  • PSA DT
  • PSA kinetics
  • Radiation
  • Surgery

ASJC Scopus subject areas

  • Urology

Cite this

Implications of Prostate-Specific Antigen Doubling Time as Indicator of Failure after Surgery or Radiation Therapy for Prostate Cancer{A figure is presented}. / Maffezzini, Massimo; Bossi, Alberto; Collette, Laurence.

In: European Urology, Vol. 51, No. 3, 03.2007, p. 605-613.

Research output: Contribution to journalArticle

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abstract = "Objectives: To review the methodology of PSA doubling time (PSA DT) calculations and the implications of PSA DT for the follow-up of prostate cancer patients curatively treated with surgery or radiation therapy. Methods: A literature search of the most recent articles on PSA DT (those published after 2000) led to the selection of six studies with the largest and best-documented cohorts of patients treated with surgery or irradiation with curative intent. Results: PSA kinetics, in the form of PSA DT, is the most effective parameter for identifying patients at significant risk for mortality specific to prostate cancer. Thresholds of 3, 6, and 12 mo have shown prognostic significance both in surgical and radiation series, notwithstanding differences in treatment selection, definition of biochemical recurrence, and methods of DT calculation. Conclusions: In retrospective studies, PSA DT is a reliable predictor of prognosis; however, prospective validation studies are needed to determine the cut points of PSA DT. Optimal time intervals for calculation and optimal thresholds are still to be determined.",
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