Implicit learning deficit in children with Duchenne muscular dystrophy: Evidence for a cerebellar cognitive impairment?

Research output: Contribution to journalArticle

Abstract

This study aimed at comparing implicit sequence learning in individuals affected by Duchenne Muscular Dystrophy without intellectual disability and age-matched typically developing children. A modified version of the Serial Reaction Time task was administered to 32 Duchenne children and 37 controls of comparable chronological age. The Duchenne group showed a reduced rate of implicit learning even if in the absence of global intellectual disability. This finding provides further evidence of the involvement of specific aspects of cognitive function in Duchenne muscular dystrophy and on its possible neurobiological substrate.

Original languageEnglish
Pages (from-to)e0191164
Number of pages10
JournalPLoS One
Volume13
Issue number1
DOIs
Publication statusPublished - Jan 16 2018

Fingerprint

muscular dystrophy
Duchenne Muscular Dystrophy
Intellectual Disability
learning
Learning
Substrates
cognition
Cognition
Reaction Time
Cognitive Dysfunction

Keywords

  • Case-Control Studies
  • Cerebellum/physiopathology
  • Child
  • Cognitive Dysfunction/complications
  • Humans
  • Learning/physiology
  • Learning Disorders/complications
  • Logistic Models
  • Male
  • Muscular Dystrophy, Duchenne/complications
  • Reaction Time/physiology

Cite this

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title = "Implicit learning deficit in children with Duchenne muscular dystrophy: Evidence for a cerebellar cognitive impairment?",
abstract = "This study aimed at comparing implicit sequence learning in individuals affected by Duchenne Muscular Dystrophy without intellectual disability and age-matched typically developing children. A modified version of the Serial Reaction Time task was administered to 32 Duchenne children and 37 controls of comparable chronological age. The Duchenne group showed a reduced rate of implicit learning even if in the absence of global intellectual disability. This finding provides further evidence of the involvement of specific aspects of cognitive function in Duchenne muscular dystrophy and on its possible neurobiological substrate.",
keywords = "Case-Control Studies, Cerebellum/physiopathology, Child, Cognitive Dysfunction/complications, Humans, Learning/physiology, Learning Disorders/complications, Logistic Models, Male, Muscular Dystrophy, Duchenne/complications, Reaction Time/physiology",
author = "Stefano Vicari and Giorgia Piccini and Eugenio Mercuri and Roberta Battini and Daniela Chieffo and Sara Bulgheroni and Chiara Pecini and Simona Lucibello and Sara Lenzi and Federica Moriconi and Marika Pane and Adele D'Amico and Guja Astrea and Giovanni Baranello and Daria Riva and Giovanni Cioni and Paolo Alfieri",
year = "2018",
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language = "English",
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journal = "PLoS One",
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T1 - Implicit learning deficit in children with Duchenne muscular dystrophy

T2 - Evidence for a cerebellar cognitive impairment?

AU - Vicari, Stefano

AU - Piccini, Giorgia

AU - Mercuri, Eugenio

AU - Battini, Roberta

AU - Chieffo, Daniela

AU - Bulgheroni, Sara

AU - Pecini, Chiara

AU - Lucibello, Simona

AU - Lenzi, Sara

AU - Moriconi, Federica

AU - Pane, Marika

AU - D'Amico, Adele

AU - Astrea, Guja

AU - Baranello, Giovanni

AU - Riva, Daria

AU - Cioni, Giovanni

AU - Alfieri, Paolo

PY - 2018/1/16

Y1 - 2018/1/16

N2 - This study aimed at comparing implicit sequence learning in individuals affected by Duchenne Muscular Dystrophy without intellectual disability and age-matched typically developing children. A modified version of the Serial Reaction Time task was administered to 32 Duchenne children and 37 controls of comparable chronological age. The Duchenne group showed a reduced rate of implicit learning even if in the absence of global intellectual disability. This finding provides further evidence of the involvement of specific aspects of cognitive function in Duchenne muscular dystrophy and on its possible neurobiological substrate.

AB - This study aimed at comparing implicit sequence learning in individuals affected by Duchenne Muscular Dystrophy without intellectual disability and age-matched typically developing children. A modified version of the Serial Reaction Time task was administered to 32 Duchenne children and 37 controls of comparable chronological age. The Duchenne group showed a reduced rate of implicit learning even if in the absence of global intellectual disability. This finding provides further evidence of the involvement of specific aspects of cognitive function in Duchenne muscular dystrophy and on its possible neurobiological substrate.

KW - Case-Control Studies

KW - Cerebellum/physiopathology

KW - Child

KW - Cognitive Dysfunction/complications

KW - Humans

KW - Learning/physiology

KW - Learning Disorders/complications

KW - Logistic Models

KW - Male

KW - Muscular Dystrophy, Duchenne/complications

KW - Reaction Time/physiology

U2 - 10.1371/journal.pone.0191164

DO - 10.1371/journal.pone.0191164

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VL - 13

SP - e0191164

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 1

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