Importance of B cell co-stimulation in CD4+ T cell differentiation: X-linked agammaglobulinaemia, a human model

H. Martini, V. Enright, M. Perro, S. Workman, J. Birmelin, E. Giorda, I. Quinti, V. Lougaris, M. Baronio, K. Warnatz, B. Grimbacher

Research output: Contribution to journalArticlepeer-review

Abstract

Summary: We were interested in the question of whether the congenital lack of B cells actually had any influence on the development of the T cell compartment in patients with agammaglobulinaemia. Sixteen patients with X-linked agammaglobulinaemia (XLA) due to mutations in Btk, nine patients affected by common variable immune deficiency (CVID) with +CD45RO+ and CD4+CD45RO+CXCR5+ cells and both subsets were decreased significantly when compared to healthy controls: P=0·001 and P

Original languageEnglish
Pages (from-to)381-387
Number of pages7
JournalClinical and Experimental Immunology
Volume164
Issue number3
DOIs
Publication statusPublished - Jun 2011

Keywords

  • CD4 T memory cells
  • CD4CD45ROCXCR5 cells
  • TFH cells
  • XLA

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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