Importance of B cell co-stimulation in CD4+ T cell differentiation: X-linked agammaglobulinaemia, a human model

H. Martini, V. Enright, M. Perro, S. Workman, J. Birmelin, E. Giorda, I. Quinti, V. Lougaris, M. Baronio, K. Warnatz, B. Grimbacher

Research output: Contribution to journalArticle

Abstract

Summary: We were interested in the question of whether the congenital lack of B cells actually had any influence on the development of the T cell compartment in patients with agammaglobulinaemia. Sixteen patients with X-linked agammaglobulinaemia (XLA) due to mutations in Btk, nine patients affected by common variable immune deficiency (CVID) with +CD45RO+ and CD4+CD45RO+CXCR5+ cells and both subsets were decreased significantly when compared to healthy controls: P=0·001 and P

Original languageEnglish
Pages (from-to)381-387
Number of pages7
JournalClinical and Experimental Immunology
Volume164
Issue number3
DOIs
Publication statusPublished - Jun 2011

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Cell Differentiation
B-Lymphocytes
T-Lymphocytes
Common Variable Immunodeficiency
Agammaglobulinemia
Mutation
Bruton type agammaglobulinemia

Keywords

  • CD4 T memory cells
  • CD4CD45ROCXCR5 cells
  • TFH cells
  • XLA

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Importance of B cell co-stimulation in CD4+ T cell differentiation : X-linked agammaglobulinaemia, a human model. / Martini, H.; Enright, V.; Perro, M.; Workman, S.; Birmelin, J.; Giorda, E.; Quinti, I.; Lougaris, V.; Baronio, M.; Warnatz, K.; Grimbacher, B.

In: Clinical and Experimental Immunology, Vol. 164, No. 3, 06.2011, p. 381-387.

Research output: Contribution to journalArticle

Martini, H, Enright, V, Perro, M, Workman, S, Birmelin, J, Giorda, E, Quinti, I, Lougaris, V, Baronio, M, Warnatz, K & Grimbacher, B 2011, 'Importance of B cell co-stimulation in CD4+ T cell differentiation: X-linked agammaglobulinaemia, a human model', Clinical and Experimental Immunology, vol. 164, no. 3, pp. 381-387. https://doi.org/10.1111/j.1365-2249.2011.04377.x
Martini, H. ; Enright, V. ; Perro, M. ; Workman, S. ; Birmelin, J. ; Giorda, E. ; Quinti, I. ; Lougaris, V. ; Baronio, M. ; Warnatz, K. ; Grimbacher, B. / Importance of B cell co-stimulation in CD4+ T cell differentiation : X-linked agammaglobulinaemia, a human model. In: Clinical and Experimental Immunology. 2011 ; Vol. 164, No. 3. pp. 381-387.
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