Abstract
Summary: We were interested in the question of whether the congenital lack of B cells actually had any influence on the development of the T cell compartment in patients with agammaglobulinaemia. Sixteen patients with X-linked agammaglobulinaemia (XLA) due to mutations in Btk, nine patients affected by common variable immune deficiency (CVID) with +CD45RO+ and CD4+CD45RO+CXCR5+ cells and both subsets were decreased significantly when compared to healthy controls: P=0·001 and P
Original language | English |
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Pages (from-to) | 381-387 |
Number of pages | 7 |
Journal | Clinical and Experimental Immunology |
Volume | 164 |
Issue number | 3 |
DOIs | |
Publication status | Published - Jun 2011 |
Keywords
- CD4 T memory cells
- CD4CD45ROCXCR5 cells
- TFH cells
- XLA
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy