Importance of B cell co-stimulation in CD4+ T cell differentiation: X-linked agammaglobulinaemia, a human model

H. Martini; V. Enright; M. Perro; S. Workman; J. Birmelin; E. Giorda; I. Quinti; V. Lougaris; M. Baronio; K. Warnatz; B. Grimbacher

doi:10.1111/j.1365-2249.2011.04377.x

Importance of B cell co-stimulation in CD4+ T cell differentiation: X-linked agammaglobulinaemia, a human model

H. Martini, V. Enright, M. Perro, S. Workman, J. Birmelin, E. Giorda, I. Quinti, V. Lougaris, M. Baronio, K. Warnatz, B. Grimbacher

Ospedale Pediatrico Bambino Gesu

Research output: Contribution to journal › Article

Abstract

Summary: We were interested in the question of whether the congenital lack of B cells actually had any influence on the development of the T cell compartment in patients with agammaglobulinaemia. Sixteen patients with X-linked agammaglobulinaemia (XLA) due to mutations in Btk, nine patients affected by common variable immune deficiency (CVID) with +CD45RO⁺ and CD4⁺CD45RO⁺CXCR5⁺ cells and both subsets were decreased significantly when compared to healthy controls: P=0·001 and P

Original language	English
Pages (from-to)	381-387
Number of pages	7
Journal	Clinical and Experimental Immunology
Volume	164
Issue number	3
DOIs	https://doi.org/10.1111/j.1365-2249.2011.04377.x
Publication status	Published - Jun 2011

Keywords

CD4 T memory cells
CD4CD45ROCXCR5 cells
TFH cells
XLA

ASJC Scopus subject areas

Immunology
Immunology and Allergy

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Martini, H., Enright, V., Perro, M., Workman, S., Birmelin, J., Giorda, E., Quinti, I., Lougaris, V., Baronio, M., Warnatz, K., & Grimbacher, B. (2011). Importance of B cell co-stimulation in CD4+ T cell differentiation: X-linked agammaglobulinaemia, a human model. Clinical and Experimental Immunology, 164(3), 381-387. https://doi.org/10.1111/j.1365-2249.2011.04377.x

Importance of B cell co-stimulation in CD4+ T cell differentiation : X-linked agammaglobulinaemia, a human model. / Martini, H.; Enright, V.; Perro, M.; Workman, S.; Birmelin, J.; Giorda, E.; Quinti, I.; Lougaris, V.; Baronio, M.; Warnatz, K.; Grimbacher, B.

In: Clinical and Experimental Immunology, Vol. 164, No. 3, 06.2011, p. 381-387.

Research output: Contribution to journal › Article

Martini, H, Enright, V, Perro, M, Workman, S, Birmelin, J, Giorda, E, Quinti, I, Lougaris, V, Baronio, M, Warnatz, K & Grimbacher, B 2011, 'Importance of B cell co-stimulation in CD4+ T cell differentiation: X-linked agammaglobulinaemia, a human model', Clinical and Experimental Immunology, vol. 164, no. 3, pp. 381-387. https://doi.org/10.1111/j.1365-2249.2011.04377.x

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