Drugs are frequently effective because they are biotransformed into metabolites. The presence of these metabolites may be suspected when the parent compound is found in a target organ for a shorter time than the duration of the biochemical, pharmacological or toxicological effect or when a given activity in vivo cannot be observed in vitro. In some cases the metabolite may be easily detected whereas in other cases it may be highly reactive and bound to macromolecules. Examples of different drugs whose biotransformation results in active metabolites are given.
|Number of pages||12|
|Journal||European Journal of Drug Metabolism and Pharmacokinetics|
|Publication status||Published - Apr 1983|
- active metabolites
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)