Importance of increased ultrafiltration volume and impact on mortality: Sepsis and cytokine story and the role for CVVH

Claudio Ronco, Z. Ricci, R. Bellomo

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

There is growing interest in extracorporeal blood purification therapies (EBPT) as adjuvants in the complex therapy of sepsis and multiple organ dysfunction syndrome (MODS). Nowadays the only routinely used purification technique is 'renal replacement therapy' (RRT) during acute renal failure (ARF), one of the almost inevitable and deadly components of MODS. RRT has been the first and still is the most utilised and effective type of EBPT. Evidence is growing about its ability to maintain homeostatic balance in critically ill patients, and specifically in septic patients with MODS. Clinical trials have been recently designed to modify or improve these therapies. In detail, the following issues have been currently addressed: effects on blood purification provided by different therapies, adequacy of prescription and delivery of therapy, toxins and solutes to be removed with these techniques. Based on these speculations we will briefly review the current understanding of these issues and the rationale for application of RRT in the intensive care unit (ICU). In particular, we will focus on the importance of increased ultrafiltration volume and its impact on mortality in the general ICU population and in septic patients.

Original languageEnglish
Pages (from-to)13-18
Number of pages6
JournalEDTNA-ERCA Journal
Volume28
Issue numberSUPPL. 2
Publication statusPublished - 2002

Fingerprint

Ultrafiltration
Sepsis
Cytokines
Renal Replacement Therapy
Multiple Organ Failure
Mortality
Intensive Care Units
Therapeutics
Acute Kidney Injury
Critical Illness
Prescriptions
Clinical Trials
Population

Keywords

  • Cytokine
  • Mortality
  • Renal replacement therapy
  • Ultrafiltration

ASJC Scopus subject areas

  • Nephrology

Cite this

Importance of increased ultrafiltration volume and impact on mortality : Sepsis and cytokine story and the role for CVVH. / Ronco, Claudio; Ricci, Z.; Bellomo, R.

In: EDTNA-ERCA Journal, Vol. 28, No. SUPPL. 2, 2002, p. 13-18.

Research output: Contribution to journalArticle

@article{640651d42fa84bd58cfff1be68278402,
title = "Importance of increased ultrafiltration volume and impact on mortality: Sepsis and cytokine story and the role for CVVH",
abstract = "There is growing interest in extracorporeal blood purification therapies (EBPT) as adjuvants in the complex therapy of sepsis and multiple organ dysfunction syndrome (MODS). Nowadays the only routinely used purification technique is 'renal replacement therapy' (RRT) during acute renal failure (ARF), one of the almost inevitable and deadly components of MODS. RRT has been the first and still is the most utilised and effective type of EBPT. Evidence is growing about its ability to maintain homeostatic balance in critically ill patients, and specifically in septic patients with MODS. Clinical trials have been recently designed to modify or improve these therapies. In detail, the following issues have been currently addressed: effects on blood purification provided by different therapies, adequacy of prescription and delivery of therapy, toxins and solutes to be removed with these techniques. Based on these speculations we will briefly review the current understanding of these issues and the rationale for application of RRT in the intensive care unit (ICU). In particular, we will focus on the importance of increased ultrafiltration volume and its impact on mortality in the general ICU population and in septic patients.",
keywords = "Cytokine, Mortality, Renal replacement therapy, Ultrafiltration",
author = "Claudio Ronco and Z. Ricci and R. Bellomo",
year = "2002",
language = "English",
volume = "28",
pages = "13--18",
journal = "Journal of Renal Care",
issn = "1019-083X",
publisher = "Wiley-Blackwell",
number = "SUPPL. 2",

}

TY - JOUR

T1 - Importance of increased ultrafiltration volume and impact on mortality

T2 - Sepsis and cytokine story and the role for CVVH

AU - Ronco, Claudio

AU - Ricci, Z.

AU - Bellomo, R.

PY - 2002

Y1 - 2002

N2 - There is growing interest in extracorporeal blood purification therapies (EBPT) as adjuvants in the complex therapy of sepsis and multiple organ dysfunction syndrome (MODS). Nowadays the only routinely used purification technique is 'renal replacement therapy' (RRT) during acute renal failure (ARF), one of the almost inevitable and deadly components of MODS. RRT has been the first and still is the most utilised and effective type of EBPT. Evidence is growing about its ability to maintain homeostatic balance in critically ill patients, and specifically in septic patients with MODS. Clinical trials have been recently designed to modify or improve these therapies. In detail, the following issues have been currently addressed: effects on blood purification provided by different therapies, adequacy of prescription and delivery of therapy, toxins and solutes to be removed with these techniques. Based on these speculations we will briefly review the current understanding of these issues and the rationale for application of RRT in the intensive care unit (ICU). In particular, we will focus on the importance of increased ultrafiltration volume and its impact on mortality in the general ICU population and in septic patients.

AB - There is growing interest in extracorporeal blood purification therapies (EBPT) as adjuvants in the complex therapy of sepsis and multiple organ dysfunction syndrome (MODS). Nowadays the only routinely used purification technique is 'renal replacement therapy' (RRT) during acute renal failure (ARF), one of the almost inevitable and deadly components of MODS. RRT has been the first and still is the most utilised and effective type of EBPT. Evidence is growing about its ability to maintain homeostatic balance in critically ill patients, and specifically in septic patients with MODS. Clinical trials have been recently designed to modify or improve these therapies. In detail, the following issues have been currently addressed: effects on blood purification provided by different therapies, adequacy of prescription and delivery of therapy, toxins and solutes to be removed with these techniques. Based on these speculations we will briefly review the current understanding of these issues and the rationale for application of RRT in the intensive care unit (ICU). In particular, we will focus on the importance of increased ultrafiltration volume and its impact on mortality in the general ICU population and in septic patients.

KW - Cytokine

KW - Mortality

KW - Renal replacement therapy

KW - Ultrafiltration

UR - http://www.scopus.com/inward/record.url?scp=0036363837&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036363837&partnerID=8YFLogxK

M3 - Article

C2 - 12371715

AN - SCOPUS:0036363837

VL - 28

SP - 13

EP - 18

JO - Journal of Renal Care

JF - Journal of Renal Care

SN - 1019-083X

IS - SUPPL. 2

ER -