Importance of the presence of necrosis in studying drug distribution within tumor tissue

M. G. Donelli, M. Broggini, T. Colombo, S. Garattini

Research output: Contribution to journalArticle

Abstract

The differential distribution of antitumoral agents such as adriamycin, methylnitrosourea, cyclophosphamide and methotrexate in the vegetating and necrotic part of the intramuscular Lewis Lung carcinoma of C57B1 mice is investigated. As expected, these drugs are found to be mostly absent in the necrotic, while accumulating in the viable part of the tumor. Our findings suggest that measurement of antitumoral agents at the tumor level should be performed in the viable part of the tumor in order to get a proper estimate of the actual drug concentrations reached.

Original languageEnglish
Pages (from-to)63-67
Number of pages5
JournalEuropean Journal of Drug Metabolism and Pharmacokinetics
Volume2
Issue number2
DOIs
Publication statusPublished - Apr 1977

Keywords

  • Antitumoral agents
  • Drug distribution
  • Lewis Lung Carcinoma
  • Necrosis

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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