Impressive long-term response with chemo-endocrine therapy in a premenopausal patient with metastatic breast cancer: A case report

Research output: Contribution to journalArticlepeer-review

Abstract

RATIONALE: Patients with, or who develop, metastatic breast cancer have a 5-year relative survival of about 25%. Endocrine therapy clearly improves outcomes in patients with estrogen receptor-positive breast cancer. In the metastatic setting, the primary goal of treatment is to maintain long-term disease control with good quality of life. Rarely, exceptional responders achieve durable disease control, and potential cures cannot be ruled out.

PATIENT CONCERNS: We report the case of a 39-year-old woman with primary breast cancer and associated synchronous bone metastases, who experienced a disease response of 12 years with hormonal therapy as maintenance after first line chemotherapy, with a good toxicity profile.

DIAGNOSIS: The patient was diagnosed with estrogen receptor + human epidermal growth factor receptor 2 (HER2)- metastatic breast cancer with synchronous bone metastases.

INTERVENTIONS: This patient was treated with chemotherapy for 6 cycles as a first-line therapy following by endocrine treatment given as a maintenance therapy.

OUTCOMES: Our patient experienced a progression-free survival >12 years with an exceptionally good quality of life.

LESSONS: Our anecdotal experience highlights the existence of exceptional responders among patients with hormone receptor-positive metastatic breast cancer, who achieve clinical remission and durable disease control with endocrine therapy. Being able to identify these patients could help in the selection of the best treatment option among the many available.

Original languageEnglish
Pages (from-to)e20396
JournalMedicine
Volume99
Issue number24
DOIs
Publication statusPublished - Jun 12 2020

Keywords

  • Adult
  • Antineoplastic Agents/therapeutic use
  • Antineoplastic Agents, Hormonal/therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols/therapeutic use
  • Bone Neoplasms/drug therapy
  • Breast Neoplasms/drug therapy
  • Female
  • Humans
  • Progression-Free Survival
  • Quality of Life
  • Receptor, ErbB-2/genetics
  • Receptors, Estrogen/genetics
  • Treatment Outcome

Fingerprint

Dive into the research topics of 'Impressive long-term response with chemo-endocrine therapy in a premenopausal patient with metastatic breast cancer: A case report'. Together they form a unique fingerprint.

Cite this