@article{ca0ea22b37494cae901356bc5825fb0e,
title = "Impressive tissue regeneration of severe oral mucositis post stem cell transplantation using cord blood platelet gel",
abstract = "BACKGROUND: Platelet gel from cord blood (CBPG) is a recently developed blood component for topical use. We report a case of life-threatening mucositis after high-dose chemotherapy with fotemustine and cytarabine that was successfully treated with CBPG. CASE REPORT: A patient with non-Hodgkin lymphoma who was undergoing autologous hematopoietic stem cell transplantation developed severe oral and esophageal mucositis with severe bacterial sepsis and cytomegalovirus infection, causing prolonged neutropenia. CBPG was topically administered daily to the oral cavity. The CBPG was partially reabsorbed and partially swallowed. RESULTS: After 8 consecutive days of administration, the patient's oral mucosa markedly improved, showing restitutio ad integrum, and the patient's clinical status progressively improved. No side effects were seen after CBPG application. CONCLUSION: This case supports the need to conduct controlled studies comparing the efficacy of autologous and allogeneic platelet gel from adult and umbilical cord blood for the topical treatment of severe oral mucositis occurring after high-dose chemotherapy. {\textcopyright} 2017 AABB",
keywords = "aciclovir, bendamustine, cytarabine, dexamethasone, etoposide, foscarnet sodium, fotemustine, melphalan, oxaliplatin, piperacillin, rituximab, tazobactam, vancomycin, gel, aged, Article, autologous hematopoietic stem cell transplantation, bacterial infection, blood component therapy, blood culture, cancer combination chemotherapy, cancer diagnosis, cancer patient, case report, clinical article, Cytomegalovirus, cytomegalovirus infection, disease severity, disseminated intravascular clotting, drug megadose, female, general condition improvement, human, immunohistochemistry, mouth cavity, mouth mucosa, multiple cycle treatment, neutropenia, neutrophil count, nonhodgkin lymphoma, oral mucositis, polymerase chain reaction, respiratory failure, sepsis, septic shock, thrombocyte, tissue regeneration, topical treatment, transfusion medicine, umbilical cord blood, administration and dosage, chemically induced, cytology, drug effects, fetus blood, hematopoietic stem cell transplantation, physiology, regeneration, stomatitis, therapeutic use, Aged, Blood Platelets, Cytarabine, Cytomegalovirus Infections, Female, Fetal Blood, Gels, Hematopoietic Stem Cell Transplantation, Humans, Mouth Mucosa, Regeneration, Sepsis, Stomatitis",
author = "A. Piccin and P. Rebulla and S. Pupella and M. Tagnin and G. Marano and {Di Pierro}, A.M. and M. Santodirocco and {Di Mauro}, L. and L. Beqiri and M. Kob and M. Primerano and M. Casini and A. Billio and K. Eisendle and F. Fontanella",
note = "Export Date: 13 April 2018 CODEN: TRANA Correspondence Address: Piccin, A.; Hematology Department, San Maurizio Regional HospitalItaly; email: apiccin@gmail.com Chemicals/CAS: aciclovir, 59277-89-3; bendamustine, 16506-27-7, 3543-75-7; cytarabine, 147-94-4, 69-74-9; dexamethasone, 50-02-2; etoposide, 33419-42-0, 433304-61-1; foscarnet sodium, 63585-09-1; fotemustine, 92118-27-9; melphalan, 148-82-3; oxaliplatin, 61825-94-3; piperacillin, 59703-84-3, 61477-96-1; rituximab, 174722-31-7; tazobactam, 93528-38-2; vancomycin, 1404-90-6, 1404-93-9; Cytarabine; Gels Tradenames: foscavir, Pfizer Manufacturers: Pfizer References: Scully, C., Sonis, S., Diz, P.D., Oral mucositis (2006) Oral Dis, 12, pp. 229-241; Duncan, G.G., Epstein, J.B., Tu, D., Quality of life, mucositis, and xerostomia from radiotherapy for head and neck cancers: a report from the NCIC CTG HN2 randomized trial of an antimicrobial lozenge to prevent mucositis (2005) Head Neck, 27, pp. 421-428; Rapoport, A.P., Miller Watelet, L.F., Linder, T., Analysis of factors that correlate with mucositis in recipients of autologous and allogeneic stem-cell transplants (1999) J Clin Oncol, 17, pp. 2446-2453; Lalla, R.V., Sonis, S.T., Peterson, D.E., Management of oral mucositis in patients who have cancer (2008) Dent Clin North Am, 52, pp. 61-77; Keefe, D.M., Schubert, M.M., Elting, L.S., Updated clinical practice guidelines for the prevention and treatment of mucositis (2007) Cancer, pp. 820-831; Di Staso, M., Rughetti, A., Dell'Orso, L., Topical application of platelet supernatant gel in the management of radiotherapy-induced mucositis: a case report (2014) Blood Transfus, 12, pp. 107-110; Aielli, F., Giusti, R., Rughetti, A., Rapid resolution of refractory chemotherapy-induced oral mucositis with platelet gel-released supernatant in a pediatric cancer patient: a case report (2014) J Pain Symptom Manage, 48, pp. e2-4; Longo, V., Rebulla, P., Pupella, S., Proteomic characterization of platelet gel releasate from adult peripheral and cord blood (2016) Proteomics Clin Appl, 10, pp. 870-882; Piccin, A., Di Pierro, A.M., Corvetta, D., Severe skin radiodermatitis fully healed with the use of platelet gel and a hyperbaric chamber (2015) Blood Transfus, 14, pp. 552-554; Piccin, A., Di Pierro, A.M., Tagnin, M., Healing of a soft tissue wound of the neck and jaw osteoradionecrosis using platelet gel (2016) Regen Med, 11, pp. 459-463; Aprili, G., Gandini, G., Guaschino, R., SIMTI recommendations on blood components for non-transfusional use (2013) Blood Transfus, 11, pp. 611-622; Rebulla, P., Pupella, S., Santodirocco, M., Multicentre standardisation of a clinical grade procedure for the preparation of allogeneic platelet concentrates from umbilical cord blood. Italian Cord Blood Platelet Gel Study Group (2016) Blood Transfus, 14, pp. 73-79; Musso, M., Scalone, R., Marcacci, G., Fotemustine plus etoposide, cytarabine and melphalan (FEAM) as a new conditioning regimen for lymphoma patients undergoing auto-SCT: a multicenter feasibility study (2010) Bone Marrow Transplant, 45, pp. 1147-1153; Tadini, G., Guez, S., Pezzani, L., Preliminary evaluation of cord blood platelet gel for the treatment of skin lesions in children with dystrophic epidermolysis bullosa (2014) Blood Transfus, 29, pp. 1-6; Tadini, G., Pezzani, L., Ghirardello, S., Cord blood platelet gel treatment of dystrophic recessive epidermolysis bullosa (2015) BMJ Case Rep, p. 2015; Liu, C.Y., Battaglia, M., Lee, S.H., Platelet factor 4 differentially modulates CD4+CD25+ (regulatory) versus CD4+CD25− (nonregulatory) T cells (2005) J Immunol, 174, pp. 2680-2686; Lange, A., Dlubek, D., Drabczak-Skrzypek, D., A high proportion of CD4+CD25+ lymphocytes associates with a risk of aGvHD and inversely correlate with proportions of CMV and EBV specific CD8+ cells in blood (2006) Blood, 108, p. 2855",
year = "2017",
doi = "10.1111/trf.14205",
language = "English",
volume = "57",
pages = "2220--2224",
journal = "Transfusion",
issn = "0041-1132",
publisher = "Blackwell Publishing Inc.",
number = "9",
}