Impressive tissue regeneration of severe oral mucositis post stem cell transplantation using cord blood platelet gel

A. Piccin, P. Rebulla, S. Pupella, M. Tagnin, G. Marano, A.M. Di Pierro, M. Santodirocco, L. Di Mauro, L. Beqiri, M. Kob, M. Primerano, M. Casini, A. Billio, K. Eisendle, F. Fontanella

Research output: Contribution to journalArticlepeer-review


BACKGROUND: Platelet gel from cord blood (CBPG) is a recently developed blood component for topical use. We report a case of life-threatening mucositis after high-dose chemotherapy with fotemustine and cytarabine that was successfully treated with CBPG. CASE REPORT: A patient with non-Hodgkin lymphoma who was undergoing autologous hematopoietic stem cell transplantation developed severe oral and esophageal mucositis with severe bacterial sepsis and cytomegalovirus infection, causing prolonged neutropenia. CBPG was topically administered daily to the oral cavity. The CBPG was partially reabsorbed and partially swallowed. RESULTS: After 8 consecutive days of administration, the patient's oral mucosa markedly improved, showing restitutio ad integrum, and the patient's clinical status progressively improved. No side effects were seen after CBPG application. CONCLUSION: This case supports the need to conduct controlled studies comparing the efficacy of autologous and allogeneic platelet gel from adult and umbilical cord blood for the topical treatment of severe oral mucositis occurring after high-dose chemotherapy. © 2017 AABB
Original languageEnglish
Pages (from-to)2220-2224
Number of pages5
Issue number9
Publication statusPublished - 2017


  • aciclovir
  • bendamustine
  • cytarabine
  • dexamethasone
  • etoposide
  • foscarnet sodium
  • fotemustine
  • melphalan
  • oxaliplatin
  • piperacillin
  • rituximab
  • tazobactam
  • vancomycin
  • gel
  • aged
  • Article
  • autologous hematopoietic stem cell transplantation
  • bacterial infection
  • blood component therapy
  • blood culture
  • cancer combination chemotherapy
  • cancer diagnosis
  • cancer patient
  • case report
  • clinical article
  • Cytomegalovirus
  • cytomegalovirus infection
  • disease severity
  • disseminated intravascular clotting
  • drug megadose
  • female
  • general condition improvement
  • human
  • immunohistochemistry
  • mouth cavity
  • mouth mucosa
  • multiple cycle treatment
  • neutropenia
  • neutrophil count
  • nonhodgkin lymphoma
  • oral mucositis
  • polymerase chain reaction
  • respiratory failure
  • sepsis
  • septic shock
  • thrombocyte
  • tissue regeneration
  • topical treatment
  • transfusion medicine
  • umbilical cord blood
  • administration and dosage
  • chemically induced
  • cytology
  • drug effects
  • fetus blood
  • hematopoietic stem cell transplantation
  • physiology
  • regeneration
  • stomatitis
  • therapeutic use
  • Aged
  • Blood Platelets
  • Cytarabine
  • Cytomegalovirus Infections
  • Female
  • Fetal Blood
  • Gels
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Mouth Mucosa
  • Regeneration
  • Sepsis
  • Stomatitis


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