Improved left ventricular function after short-term treatment with fructose-1,6-diphosphate: Echocardiographic study in chronic ischemic heart disease and idiopathic dilated cardiomyopathy

A. M. Grandi, C. Muggia, F. Barzizza, A. Venco, G. Finardi

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of fructose-1,6-diphosphate (FDP) on left ventricular function was assessed in seven patients with chronic ischemic heart disease and eight patients with idiopathic dilated cardiomyopathy. In a crossover study design each patient received 10 gm of FDP or saline placebo intravenously for three days. An M-mode echocardiographic assessment of left ventricular (LV) function was made before and after each treatment period. After FDP treatment, LV end-diastolic and systolic dimensions showed a 6% reduction (P <0.01), while peak lengthening rate of LV dimension in diastole and peak shortening rate of LV dimension in systole increased 17% and 10%, respectively (P <0.05). There was evidence that FDP was more effective in the patients with ischemic heart disease than in the patients with cardiomyopathy.

Original languageEnglish
Pages (from-to)372-380
Number of pages9
JournalClinical Therapeutics
Volume10
Issue number4
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Pharmacology

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