TY - JOUR
T1 - Improved symptom profiles and minimal inflammation in IBS-d patients undergoing a long-term low-fodmap diet
T2 - A lipidomic perspective
AU - Orlando, Antonella
AU - Tutino, Valeria
AU - Notarnicola, Maria
AU - Riezzo, Giuseppe
AU - Linsalata, Michele
AU - Clemente, Caterina
AU - Prospero, Laura
AU - Martulli, Manuela
AU - D’attoma, Benedetta
AU - De Nunzio, Valentina
AU - Russo, Francesco
N1 - Funding Information:
Funding: This research was funded by the Italian Ministry of Health (Grant n. 45-24.01.2017).
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/6
Y1 - 2020/6
N2 - Given the link between the minimal inflammation underlying irritable bowel syndrome (IBS) and dietary treatments, considerable attention has focused on diets low in fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs). In this context, inflammatory patterns and lipidomic investigations may shed light on the pathophysiological mechanisms whereby a low-FODMAP diet (LFD) improves the IBS diarrhoea (IBS-D) variant. Thus, we investigated whether a long-term LFD induced changes in symptom profiles, anthropometric characteristics, inflammatory markers (C-reactive protein, cyclooxygenase-2, and prostaglandin E2) and erythrocyte-membrane fatty acid (FA) composition in IBS-D patients. Twenty IBS-D patients underwent a 90 day personalised LFD programme, and were regularly evaluated at scheduled visits. At the diet’s end, both IBS symptoms and anthropometric parameters were significantly improved. A significant decrease in prostaglandin E2 also accompanied these reductions. As for FAs, the putative inflammatory indicators, arachidonic acid (AA) levels and the AA/eicosapentaenoic acid ratio were significantly decreased. In conclusion, IBS-D patients following a controlled long-term LFD experienced improved symptom profiles and decreased inflammatory markers linked to FAs. Lipidomic data may be insightful for unravelling the molecular mechanisms associated with IBS-D pathophysiology.
AB - Given the link between the minimal inflammation underlying irritable bowel syndrome (IBS) and dietary treatments, considerable attention has focused on diets low in fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs). In this context, inflammatory patterns and lipidomic investigations may shed light on the pathophysiological mechanisms whereby a low-FODMAP diet (LFD) improves the IBS diarrhoea (IBS-D) variant. Thus, we investigated whether a long-term LFD induced changes in symptom profiles, anthropometric characteristics, inflammatory markers (C-reactive protein, cyclooxygenase-2, and prostaglandin E2) and erythrocyte-membrane fatty acid (FA) composition in IBS-D patients. Twenty IBS-D patients underwent a 90 day personalised LFD programme, and were regularly evaluated at scheduled visits. At the diet’s end, both IBS symptoms and anthropometric parameters were significantly improved. A significant decrease in prostaglandin E2 also accompanied these reductions. As for FAs, the putative inflammatory indicators, arachidonic acid (AA) levels and the AA/eicosapentaenoic acid ratio were significantly decreased. In conclusion, IBS-D patients following a controlled long-term LFD experienced improved symptom profiles and decreased inflammatory markers linked to FAs. Lipidomic data may be insightful for unravelling the molecular mechanisms associated with IBS-D pathophysiology.
KW - Dietetics
KW - Fatty acids
KW - FODMAPs
KW - Inflammation
KW - Irritable bowel syndrome
KW - Lipidomic analysis
KW - Red blood cell membranes
KW - Symptom assessment
UR - http://www.scopus.com/inward/record.url?scp=85086008244&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85086008244&partnerID=8YFLogxK
U2 - 10.3390/nu12061652
DO - 10.3390/nu12061652
M3 - Article
C2 - 32498383
AN - SCOPUS:85086008244
VL - 12
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 6
M1 - 1652
ER -