TY - JOUR
T1 - Improved tolerability of chemotherapy in soft tissue sarcomas
T2 - Old and new strategies
AU - Pasetto, Lara Maria
AU - Basso, Umberto
AU - Brandes, Albe Ariela
PY - 2003/4
Y1 - 2003/4
N2 - Anthracyclines and alkylating agents (ifosfamide, Mitoxana®) are the mainstays of chemotherapy for soft tissue sarcoma and as there is a close correlation between dose-intensity and response, methods should be developed to ameliorate the clinical tolerability of these agents. Improvements in the efficacy of medical treatments for soft tissue sarcomas may derive from old strategies by aiming to counteract the side effects of standard chemotherapy regimes and from new, less toxic, anticancer drugs. This paper reviews the currently available options for reducing the cardiotoxicity of anthracyclines, the role of growth factors and autologous stem cell transplantation in dose-intensification of chemotherapy and also examines the clinical impact of the more promising new agents.
AB - Anthracyclines and alkylating agents (ifosfamide, Mitoxana®) are the mainstays of chemotherapy for soft tissue sarcoma and as there is a close correlation between dose-intensity and response, methods should be developed to ameliorate the clinical tolerability of these agents. Improvements in the efficacy of medical treatments for soft tissue sarcomas may derive from old strategies by aiming to counteract the side effects of standard chemotherapy regimes and from new, less toxic, anticancer drugs. This paper reviews the currently available options for reducing the cardiotoxicity of anthracyclines, the role of growth factors and autologous stem cell transplantation in dose-intensification of chemotherapy and also examines the clinical impact of the more promising new agents.
KW - Anthracyclines
KW - Cardiotoxicity
KW - Chemotherapy
KW - High-dose chemotherapy
KW - Soft tissue sarcoma
KW - Toxicity
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U2 - 10.1586/14787210.3.2.167
DO - 10.1586/14787210.3.2.167
M3 - Article
C2 - 12722876
AN - SCOPUS:0037394273
VL - 3
SP - 167
EP - 178
JO - Expert Review of Molecular Diagnostics
JF - Expert Review of Molecular Diagnostics
SN - 1473-7159
IS - 2
ER -