Improved tolerability of chemotherapy in soft tissue sarcomas: Old and new strategies

Lara Maria Pasetto, Umberto Basso, Albe Ariela Brandes

Research output: Contribution to journalArticle

Abstract

Anthracyclines and alkylating agents (ifosfamide, Mitoxana®) are the mainstays of chemotherapy for soft tissue sarcoma and as there is a close correlation between dose-intensity and response, methods should be developed to ameliorate the clinical tolerability of these agents. Improvements in the efficacy of medical treatments for soft tissue sarcomas may derive from old strategies by aiming to counteract the side effects of standard chemotherapy regimes and from new, less toxic, anticancer drugs. This paper reviews the currently available options for reducing the cardiotoxicity of anthracyclines, the role of growth factors and autologous stem cell transplantation in dose-intensification of chemotherapy and also examines the clinical impact of the more promising new agents.

Original languageEnglish
Pages (from-to)167-178
Number of pages12
JournalExpert Review of Anticancer Therapy
Volume3
Issue number2
DOIs
Publication statusPublished - Apr 2003

Keywords

  • Anthracyclines
  • Cardiotoxicity
  • Chemotherapy
  • High-dose chemotherapy
  • Soft tissue sarcoma
  • Toxicity

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology

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