Improvement in exercise capacity after correction of anemia in patients with end-stage renal failure

Marco Metra, Giuseppe Cannella, Giovanni La Canna, Tiziana Guaini, Massimo Sandrini, Mario Gaggiotti, Ezio Movilli, Livio Dei Cas

Research output: Contribution to journalArticle

Abstract

Changes in exercise tolerance occurring after correction of anemia with recombinant human erythropoietin in a group of patients with end-stage renal failure were evaluated. Ten patients, aged 29 ± 11 years, on chronic hemodialysis treatment, with no associated diseases, were evaluated by cardiopulmonary bicycle exercise testing and M-mode, 2-dimensional and pulsed doppler echocardiography before and after anemia correction. After 1 and 3 months of therapy, hemoglobin plasma levels increased from 5.9 ± 1.2 to 7.7 ± 1.3 and 9.9 ± 1.4 g/dl, with a concomitant increase in peak oxygen consumption (VO2) from 21.4 ± 4.3 to 24.4 ± 4.3 and 26.6 ± 4.6 ml/kg/min and of VO2 at the ventilatory threshold from 15.0 ± 3.7 to 17.3 ± 3.7 and 16.8 ± 3.4 ml/kg/min. After 3 months of therapy, systolic blood pressure significantly decreased both at peak exercise (159 ± 35 to 134 ± 22 mm Hg) and ventilatory threshold (140 ± 27 to 123 ± 19 mm Hg), whereas cardiac index at rest decreased from 3.3 ± 0.7 to 2.8 ± 0.5 liters/min/m2 and heart rate from 77 ± 12 to 70 ± 10 beats/min. However, no significant relation was found between hemoglobin plasma levels and peak VO2, whereas a significant relation was found between hemoglobin concentration and cardiac index at rest.

Original languageEnglish
Pages (from-to)1060-1066
Number of pages7
JournalThe American Journal of Cardiology
Volume68
Issue number10
DOIs
Publication statusPublished - Oct 15 1991

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Chronic Kidney Failure
Anemia
Hemoglobins
Exercise
Doppler Pulsed Echocardiography
Blood Pressure
Exercise Tolerance
Erythropoietin
Oxygen Consumption
Renal Dialysis
Therapeutics
Heart Rate

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Metra, M., Cannella, G., La Canna, G., Guaini, T., Sandrini, M., Gaggiotti, M., ... Cas, L. D. (1991). Improvement in exercise capacity after correction of anemia in patients with end-stage renal failure. The American Journal of Cardiology, 68(10), 1060-1066. https://doi.org/10.1016/0002-9149(91)90496-8

Improvement in exercise capacity after correction of anemia in patients with end-stage renal failure. / Metra, Marco; Cannella, Giuseppe; La Canna, Giovanni; Guaini, Tiziana; Sandrini, Massimo; Gaggiotti, Mario; Movilli, Ezio; Cas, Livio Dei.

In: The American Journal of Cardiology, Vol. 68, No. 10, 15.10.1991, p. 1060-1066.

Research output: Contribution to journalArticle

Metra, M, Cannella, G, La Canna, G, Guaini, T, Sandrini, M, Gaggiotti, M, Movilli, E & Cas, LD 1991, 'Improvement in exercise capacity after correction of anemia in patients with end-stage renal failure', The American Journal of Cardiology, vol. 68, no. 10, pp. 1060-1066. https://doi.org/10.1016/0002-9149(91)90496-8
Metra, Marco ; Cannella, Giuseppe ; La Canna, Giovanni ; Guaini, Tiziana ; Sandrini, Massimo ; Gaggiotti, Mario ; Movilli, Ezio ; Cas, Livio Dei. / Improvement in exercise capacity after correction of anemia in patients with end-stage renal failure. In: The American Journal of Cardiology. 1991 ; Vol. 68, No. 10. pp. 1060-1066.
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