Improvement in exercise capacity after correction of anemia in patients with end-stage renal failure

Marco Metra, Giuseppe Cannella, Giovanni La Canna, Tiziana Guaini, Massimo Sandrini, Mario Gaggiotti, Ezio Movilli, Livio Dei Cas

Research output: Contribution to journalArticlepeer-review

Abstract

Changes in exercise tolerance occurring after correction of anemia with recombinant human erythropoietin in a group of patients with end-stage renal failure were evaluated. Ten patients, aged 29 ± 11 years, on chronic hemodialysis treatment, with no associated diseases, were evaluated by cardiopulmonary bicycle exercise testing and M-mode, 2-dimensional and pulsed doppler echocardiography before and after anemia correction. After 1 and 3 months of therapy, hemoglobin plasma levels increased from 5.9 ± 1.2 to 7.7 ± 1.3 and 9.9 ± 1.4 g/dl, with a concomitant increase in peak oxygen consumption (VO2) from 21.4 ± 4.3 to 24.4 ± 4.3 and 26.6 ± 4.6 ml/kg/min and of VO2 at the ventilatory threshold from 15.0 ± 3.7 to 17.3 ± 3.7 and 16.8 ± 3.4 ml/kg/min. After 3 months of therapy, systolic blood pressure significantly decreased both at peak exercise (159 ± 35 to 134 ± 22 mm Hg) and ventilatory threshold (140 ± 27 to 123 ± 19 mm Hg), whereas cardiac index at rest decreased from 3.3 ± 0.7 to 2.8 ± 0.5 liters/min/m2 and heart rate from 77 ± 12 to 70 ± 10 beats/min. However, no significant relation was found between hemoglobin plasma levels and peak VO2, whereas a significant relation was found between hemoglobin concentration and cardiac index at rest.

Original languageEnglish
Pages (from-to)1060-1066
Number of pages7
JournalThe American Journal of Cardiology
Volume68
Issue number10
DOIs
Publication statusPublished - Oct 15 1991

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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