Improvement in insulin resistance and favourable changes in plasma inflammatory adipokines after weight loss associated with two months' consumption of a combination of bioactive food ingredients in overweight subjects

Mariangela Rondanelli, Annalisa Opizzi, Simone Perna, Milena Faliva, Sebastiano Bruno Solerte, Marisa Fioravanti, Catherine Klersy, Cava Edda, Paolini Maddalena, Scavone Luciano, Ceccarelli Paola, Castellaneta Emanuela, Savina Claudia, Lorenzo Maria Donini

Research output: Contribution to journalArticlepeer-review

Abstract

This randomized, double blind, placebo-controlled, 8 week trial assessed the efficacy on metabolic changes produced by a consumption of a combination of bioactive food ingredients (epigallocatechin gallate, capsaicins, piperine and l-carnitine) versus a placebo, as part of a therapeutic 'lifestyle change' diet, in 86 overweight subjects. Forty-one patients (2/14 F/M; age 43.7 ± 8.5; BMI 30.3 ± 3.5 kg/m2) were randomized to the supplemented group and 45 (29/16; age 40.7 ± 10.2; BMI 30.0 ± 2.7) to the control group. We observed that consumption of the dietary supplement was associated with a significantly greater decrease in insulin resistance, assessed by homostasis model assessment (p <0.001), leptin/adiponectin ratio (p <0.04), respiratory quotient (p <0.008). LDL-cholesterol levels (p <0.01). Moreover, statistically significant differences were recorded between the two groups in relation to urinary norepinephrine levels (p <0.001). Leptin, ghrelin, C-reactive protein decreased and resting energy expenditure increased significantly in the supplemented group (p <0.05, 0.03, 0.02 and 0,02 respectively), but not in the placebo group; adiponectin decreased significantly in the placebo group (0.001) but not in the supplemented group, although no statistical significance between the groups was elicited. BMI, fat mass (assessed by DXA) and vascular endothelial growth factor significantly decreased, whilst the resting energy expenditure/free fat mass significantly increased in both groups. In general, a greater change was recorded in the supplemented group compared to the placebo, although no statistically significant difference between the two groups was recorded. These results suggest that the combination of bioactive food ingredients studied might be useful for the treatment of obesity-related inflammatory metabolic dysfunctions.

Original languageEnglish
Pages (from-to)391-401
Number of pages11
JournalEndocrine
Volume44
Issue number2
DOIs
Publication statusPublished - Oct 2013

Keywords

  • Adiponectin
  • Capsaicins
  • Dietary supplement
  • Epigallocatechin gallate
  • Inflammation
  • Insulin resistance
  • l-carnitine
  • Leptin
  • Obesity
  • Piperine

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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