Improvement in quality of life and activity limitations in migraine patients after prophylaxis. A prospective longitudinal multicentre study

D. D'Amico, A. Solari, S. Usai, P. Santoro, P. Bernardoni, F. Frediani, R. De Marco, N. Massetto, G. Bussone

Research output: Contribution to journalArticlepeer-review

Abstract

Improved health-related quality of life (HRQOL) and reduced activity limitations are prime objectives of migraine therapy, but no data on the effect of preventive treatments on these outcomes are available. We monitored changes in HRQOL using the Short Form 36 (SF-36) and headache-related activity limitations using the Migraine Disability Assessment Score (MIDAS) in 141 consecutive migraine without aura patients on prophylaxis. A total of 102 patients completed the 3-month study. Mean (SD) number of headache days/month dropped from 8.0 (3.7) to 5.0 (2.3) (P <0.001). Mean monthly consumption of acute drugs reduced from 7.4 (3.5) to 4.4 (3.1) (P <0.001). MIDAS total score reduced (improved) significantly. All SF-36 scale scores increased (improved), most significantly. This first study to assess prospectively the impact of prophylaxis on HRQOL and daily activities in a large series indicates that migraine prophylaxis has the potential to reduce the global burden of migraine on individuals and society.

Original languageEnglish
Pages (from-to)691-696
Number of pages6
JournalCephalalgia
Volume26
Issue number6
DOIs
Publication statusPublished - Jun 2006

Keywords

  • Activity limitations
  • Health-related quality of life (HRQoL)
  • Migraine
  • Migraine disability assessment score (MIDAS)
  • Prophylaxis
  • Short form 36 (SF-36)

ASJC Scopus subject areas

  • Clinical Neurology

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