Improvement of cognition in a patient with Cotard's delusions and frontotemporal atrophy receiving electroconvulsive therapy (ECT) for depression.

Giuseppe Fàzzari, Oliviero Benzoni, Alessio Sangaletti, Francesca Bonera, Stefano Nassini, Lorenzo Mazzarini, Isabella Pacchiarotti, Gabriele Sani, Alexia Emilia Koukopoulos, Livia Sanna, Roberto Gasparotti, Pietro De Rossi, Simone Lazanio, Valeria Savoja, Paolo Girardi

Research output: Contribution to journalArticlepeer-review

Abstract

A 69-year-old man presented with Cotard's delusions, insomnia, profound depression, amnesia, difficulty concentrating, and cognitive deficit after two different surgical interventions. Brain imaging showed frontotemporal-subcortical atrophy and lateral ventricular enlargement. He responded poorly to a combination of sertraline, amisulpride and mirtazapine, with modest benefit on insomnia, and developed hypotension. After 18 days he was switched to olanzapine and venlafaxine, but his cognition worsened. He underwent bilateral electroconvulsive therapy (ECT). His mood improved, cognitive performance increased and anxiety symptoms remitted. This improvement persisted through the one-month post-discharge follow-up and depression eventually remitted.

Original languageEnglish
Pages (from-to)600-603
Number of pages4
JournalInternational Psychogeriatrics
Volume21
Issue number3
DOIs
Publication statusPublished - Jun 2009

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Gerontology
  • Clinical Psychology

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