Improvement of executive function after short-term administration of an antioxidants mix containing bacopa, lycopene, astaxanthin and vitamin b12: The blatwelve study

Francesca Crosta, Amanda Stefani, Francesco Melani, Paolo Fabrizzi, Andrea Nizzardo, Davide Grassi, Raffaella Bocale, Stefano Necozione, Francesca Lombardi, Vanessa Castelli, Arrigo F.G. Cicero, Annamaria Cimini, Claudio Ferri, Giovambattista Desideri

Research output: Contribution to journalArticlepeer-review

Abstract

During the last few years increasing interest has been focused on antioxidants as potentially useful agents in the prevention of the onset and progression of cognitive dysfunction. In this randomized, double-blind, controlled, parallel arm study, the effects of daily consumption of an antioxidant mix on cognitive function in healthy older adults were evaluated. After a 1 week run-in period, 80 subjects aged 60 years or more, and with no evidence of cognitive dysfunction, were randomly allocated to a mix of four bioactive compounds (bacopa, lycopene, astaxanthin, and vitamin B12) or matched placebo, taken orally once a day for 8 weeks. The primary objective of the study was to evaluate the changes in trial making test (TMT) scores from baseline to 8 weeks of treatment, analyzed in the following hierarchical order: TMT-B, TMT-A, and TMT-B minus TMT-A. TMT-B increased in the control group (+3.46 s) and decreased in the active group (−17.63 s). The treatment difference was −21.01 s in favor of the active group (95% C.I. −26.80 to −15.2, p < 0.0001). The decrease in TMT-A was significantly higher in the active group (−6.86 s) than in the control group (−0.37 s). TMT-B minus TMT-A increased in the control group (+3.84 s) and decreased in the active group (−10.46 s). The increase in letter fluency in the verbal fluency test (VFT) was also significantly higher in the active group and statistically significant (+5.28 vs. +1.07 words; p < 0.001). Our findings provide encouraging evidence that regular dietary supplementation with bacopa, lycopene, astaxanthin, and vitamin B12 may be an effective dietary approach for counteracting cognitive changes associated with brain aging.

Original languageEnglish
Article number56
Pages (from-to)1-16
Number of pages16
JournalNutrients
Volume13
Issue number1
DOIs
Publication statusPublished - Jan 2021

Keywords

  • Antioxidants
  • Astaxanthin
  • Bacopa
  • Cognitive function
  • Lycopene
  • Oxidative stress
  • Vitamin B12

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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