Improvement of ischaemic left ventricular dysfunction in a clinical setting

C. Brunelli, O. Parodi, G. Sambuceti, L. Corsiglia, G. M. Rosa, A. Giorgetti, P. Spallarossa, N. Nista, G. P. Bezante, S. Caponnetto

Research output: Contribution to journalArticlepeer-review


Aim of this study was to investigate me effects of nisoldipine on regional myocardial blood flow (MBF) in dyssynergic but viable myocardium after myocardial infarction (MI). 15 patients with isolated left anterior descending coronary (LAD) stenosis were studied 1 month after first MI. Patients underwent F18-deoxyglucose imaging, while MBF was measured using positron emission tomography and 13N-ammonia, at baseline and following dobutamine infusion (10 mcg/Kg/min over 5 min, DOB). MBF measurements were repeated 24 hours later after nisoldipine (10 mg bid). Among a total of 132 LAD related regions, 30 showed normal wall motion at 2D-echo and normal metabolic activity, 68 showed wall motion abnormality and preserved deoxyglucose uptake, while 32 dyssynergic regions were necrotic. Reduced baseline MBF values were found in necrotic and dyssynergic viable regions but only viable regions maintained residual perfusion reserve. After nisoldipine treatment a significant improvement in baseline MBF occurred only in viable segments. Thus, in dyssynergic viable myocardium, nisoldipine selectively improved basal perfusion.

Original languageEnglish
Pages (from-to)61-63
Number of pages3
JournalJournal of Clinical and Basic Cardiology
Issue number1
Publication statusPublished - 1999


  • Heart
  • Hibernation
  • Ischaemia
  • Nisoldipine

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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