Abstract
The simplified synthesis of a portion of Globo-H hexasaccharide, a saccharide antigen overexpressed by breast cancer cells, and its conjugation to two different immunogenic proteins are described. The conjugated vaccines, evaluated in a preclinical model, showed good immunogenic potential.
Original language | English |
---|---|
Pages (from-to) | 4331-4336 |
Number of pages | 6 |
Journal | European Journal of Organic Chemistry |
Issue number | 22 |
Publication status | Published - Nov 2001 |
Keywords
- Carbohydrates
- Conjugate vaccine
- CRM197
- Globo-H
- KLH
ASJC Scopus subject areas
- Organic Chemistry