Improvement of the synthesis of immunological carbohydrate vaccines containing the tumour associate antigen CaMBr1

Luigi Lay; Luigi Panza; Laura Poletti; Davide Prosperi; Silvana Canevari; Maria Elisa Perico

Improvement of the synthesis of immunological carbohydrate vaccines containing the tumour associate antigen CaMBr1

Luigi Lay, Luigi Panza, Laura Poletti, Davide Prosperi, Silvana Canevari, Maria Elisa Perico

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

The simplified synthesis of a portion of Globo-H hexasaccharide, a saccharide antigen overexpressed by breast cancer cells, and its conjugation to two different immunogenic proteins are described. The conjugated vaccines, evaluated in a preclinical model, showed good immunogenic potential.

Original language	English
Pages (from-to)	4331-4336
Number of pages	6
Journal	European Journal of Organic Chemistry
Issue number	22
Publication status	Published - Nov 2001

Keywords

Carbohydrates
Conjugate vaccine
CRM197
Globo-H
KLH

ASJC Scopus subject areas

Organic Chemistry

Cite this

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title = "Improvement of the synthesis of immunological carbohydrate vaccines containing the tumour associate antigen CaMBr1",

abstract = "The simplified synthesis of a portion of Globo-H hexasaccharide, a saccharide antigen overexpressed by breast cancer cells, and its conjugation to two different immunogenic proteins are described. The conjugated vaccines, evaluated in a preclinical model, showed good immunogenic potential.",

keywords = "Carbohydrates, Conjugate vaccine, CRM197, Globo-H, KLH",

author = "Luigi Lay and Luigi Panza and Laura Poletti and Davide Prosperi and Silvana Canevari and Perico, {Maria Elisa}",

year = "2001",

month = nov,

language = "English",

pages = "4331--4336",

journal = "Justus Liebigs Annalen der Chemie",

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AU - Lay, Luigi

AU - Panza, Luigi

AU - Poletti, Laura

AU - Prosperi, Davide

AU - Canevari, Silvana

AU - Perico, Maria Elisa

PY - 2001/11

Y1 - 2001/11

N2 - The simplified synthesis of a portion of Globo-H hexasaccharide, a saccharide antigen overexpressed by breast cancer cells, and its conjugation to two different immunogenic proteins are described. The conjugated vaccines, evaluated in a preclinical model, showed good immunogenic potential.

AB - The simplified synthesis of a portion of Globo-H hexasaccharide, a saccharide antigen overexpressed by breast cancer cells, and its conjugation to two different immunogenic proteins are described. The conjugated vaccines, evaluated in a preclinical model, showed good immunogenic potential.

KW - Carbohydrates

KW - Conjugate vaccine

KW - CRM197

KW - Globo-H

KW - KLH

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M3 - Article

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JO - Justus Liebigs Annalen der Chemie

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ER -

Improvement of the synthesis of immunological carbohydrate vaccines containing the tumour associate antigen CaMBr1

Abstract

Keywords

ASJC Scopus subject areas

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