The simplified synthesis of a portion of Globo-H hexasaccharide, a saccharide antigen overexpressed by breast cancer cells, and its conjugation to two different immunogenic proteins are described. The conjugated vaccines, evaluated in a preclinical model, showed good immunogenic potential.
|Number of pages||6|
|Journal||European Journal of Organic Chemistry|
|Publication status||Published - Nov 2001|
- Conjugate vaccine
ASJC Scopus subject areas
- Organic Chemistry