Improvement of the synthesis of immunological carbohydrate vaccines containing the tumour associate antigen CaMBr1

Luigi Lay, Luigi Panza, Laura Poletti, Davide Prosperi, Silvana Canevari, Maria Elisa Perico

Research output: Contribution to journalArticlepeer-review

Abstract

The simplified synthesis of a portion of Globo-H hexasaccharide, a saccharide antigen overexpressed by breast cancer cells, and its conjugation to two different immunogenic proteins are described. The conjugated vaccines, evaluated in a preclinical model, showed good immunogenic potential.

Original languageEnglish
Pages (from-to)4331-4336
Number of pages6
JournalEuropean Journal of Organic Chemistry
Issue number22
Publication statusPublished - Nov 2001

Keywords

  • Carbohydrates
  • Conjugate vaccine
  • CRM197
  • Globo-H
  • KLH

ASJC Scopus subject areas

  • Organic Chemistry

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