Abstract
The simplified synthesis of a portion of Globo-H hexasaccharide, a saccharide antigen overexpressed by breast cancer cells, and its conjugation to two different immunogenic proteins are described. The conjugated vaccines, evaluated in a preclinical model, showed good immunogenic potential.
| Original language | English |
|---|---|
| Pages (from-to) | 4331-4336 |
| Number of pages | 6 |
| Journal | European Journal of Organic Chemistry |
| Issue number | 22 |
| Publication status | Published - Nov 2001 |
Keywords
- Carbohydrates
- Conjugate vaccine
- CRM197
- Globo-H
- KLH
ASJC Scopus subject areas
- Organic Chemistry
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Lay, L., Panza, L., Poletti, L., Prosperi, D., Canevari, S., & Perico, M. E. (2001). Improvement of the synthesis of immunological carbohydrate vaccines containing the tumour associate antigen CaMBr1. European Journal of Organic Chemistry, (22), 4331-4336.