Improvement over time in outcome for children with acute lymphoblastic leukemia in second remission given hematopoietic stem cell transplantation from unrelated donors

F. Locatelli, M. Zecca, C. Messina, R. Rondelli, E. Lanino, N. Sacchi, C. Uderzo, F. Fagioli, V. Conter, F. Bonetti, C. Favre, F. Porta, G. Giorgiani, A. Pession

Research output: Contribution to journalArticle

Abstract

Aims of this study were to verify whether reduction in transplant-related mortality (TRM) of children with acute lymphoblastic leukemia (ALL) in second complete remission (CR) given allogeneic hematopoietic stem cell transplantation (HSCT) from unrelated volunteers has occurred over time and to investigate the role of other variables on the probabilities of relapse, TRM and event-free survival (EFS). We compared results obtained in 26 children given HSCT before January 1998 with those of 37 patients transplanted beyond that date. In all donor-recipient pairs, histocompatibility was determined by serology for HLA-A and -B antigens and by high-resolution DNA typing for DRB1 antigen. High-resolution molecular typing of HLA class I antigens was employed in 20 of the 37 children transplanted more recently. Probability of both acute and chronic GVHD was comparable in the two groups of patients. In multivariate analysis, children transplanted before January 1998, those with T-lineage ALL and those experiencing grade II-IV acute GVHD had a higher relative risk of TRM at 6 months after transplantation. Relapse rate was unfavorably affected by a time interval between diagnosis and relapse

Original languageEnglish
Pages (from-to)2228-2237
Number of pages10
JournalLeukemia
Volume16
Issue number11
DOIs
Publication statusPublished - Nov 1 2002

Keywords

  • Acute lymphoblastic leukemia
  • GVHD
  • HLA typing
  • Leukemia relapse
  • Unrelated donor registries
  • Unrelated donor stem cell transplantation

ASJC Scopus subject areas

  • Hematology
  • Cancer Research

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